20.500.12556/DiRROS-17049 Neuromuscular assessment of force development, postural, and gait performance under cognitive-motor dual-tasking in healthy older adults and early Parkinson's disease patients study protocol for a cross-sectional Mobile Brain/Body Imaging (MoBI) study Background: Neuromuscular dysfunction is common in older adults and more pronounced in neurodegenerative diseases. In Parkinson's disease (PD), a complex set of factors often prevents the effective performance of activities of daily living that require intact and simultaneous performance of the motor and cognitive tasks. Methods: The cross-sectional study includes a multifactorial mixed-measure design. Between-subject factor grouping the sample will be Parkinson’s Disease (early PD vs. healthy). The within-subject factors will be the task complexity (single- vs. dual-task) in each motor activity, i.e., overground walking, semi-tandem stance, and isometric knee extension, and a walking condition (wide vs. narrow lane) will be implemented for the overground walking activity only. To study dual-task (DT) effects, in each motor activity participants will be given a secondary cognitive task, i.e., a visual discrimination task for the overground walking, an attention task for the semi-tandem, and mental arithmetic for the isometric extension. Analyses of DT effects and underlying neuronal correlates will focus on both gait and cognitive performance where applicable. Based on an a priori sample size calculation, a total N = 42 older adults (55-75 years) will be recruited. Disease-specific changes such as laterality in motor unit behavior and cortical control of movement will be studied with high-density surface electromyography and electroencephalography during static and dynamic motor activities, together with whole-body kinematics. Discussion: This study will be one of the first to holistically address early PD neurophysiological and neuromuscular patterns in an ecologically valid environment under cognitive-motor DT conditions of different complexities. The outcomes of the study aim to identify the biomarker for early PD either at the electrophysiological, muscular or kinematic level or in the communication between these systems. Parkinson's disease mobile brain imaging body brain imaging MoBi dual tasking neuromuscular function older adults mobilne telesne oslikave možganske oslikave dvojna naloga živčnomišične funkcije true false true Angleški jezik Slovenski jezik © 2023 Marusic U et al Neznano 2023-09-15 15:14:48 2023-09-15 15:14:49 2024-12-11 12:36:29 0000-00-00 00:00:00 2023 0 0 Nasl. z nasl. zaslona; Soavtorji: Manca Peskar, Maja Maša Šömen, Miloš Kalc, Ales Holobar, Klaus Gramann, Bettina Wollesen, Anna Wunderlich, Christoph Michel, Aleksandar Miladinović, Mauro Catalan, Alex Buoite Stella, Milos Ajcevic, Paolo Manganotti; Opis vira z dne 15. 9. 2023; 14 str. [article no.] ǂ58 Vol. 3 2023 0000-00-00 PostprintKoncna Objavljeno NiDoloceno 0000-00-00 0000-00-00 2023-08-25 612.82:612.76 2732-5121 10.12688/openreseurope.15781.2 164659715 ZRSKP_MarusicU_164659715.pdf ZRSKP_MarusicU_164659715.pdf 1 30753A62D30775C107A2B8C6DF82ADC8 8b1d7aff64edb52444a2dcfd6aa4e5b5ad1c5e9d2eeca0b5baeb35335c64f6b4 581fb870-53ba-11ee-8cc8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=23151 https://open-research-europe.ec.europa.eu/articles/3-58/v2 0 08b54ad6-53b9-11ee-8cc8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=23150 Znanstveno-raziskovalno središče Koper / Centro di Ricerche Scientifiche Capodistria 0 0 0