20.500.12556/DiRROS-16068-39708ed5-2d64-47d5-77c6-39fda3c59153 Rezultati študije RAPIDO Results of the RAPIDO study 3-letno preživetje brez bolezni pri bolnikih z lokalno napredovalim rakom danke je trenutno približno 50 %. Standardno zdravljenje bolnikov z visokim tveganjem za lokalno in/ali sistemsko ponovitev bolezni vključuje predoperativno radioterapijo po dolgem protokolu (5 tednov) v kombinaciji s kemoterapijo (neoadjuvantna kemoradioterapija). Dokazano je, da neoadjuvantna kemoradioterapija izboljša lokalno kontrolo, vendar ne vpliva na preživetje. Sistemski recidivi ostajajo velik problem pri lokalno napredovalem raku danke. Z namenom zmanjšanja oddaljenih metastaz brez ogrožanja lokoregionalnega nadzora z uporabo radioterapije po kratkem režimu, ki ji sledi kemoterapija in odložena operacija je bila sestavljena in izvedena študija RAPIDO (Rectal cancer And Preoperative Induction therapy followed by Dedicated Operation – RAPIDO). Šlo je za multicentrično, mednarodno študijo faze 3 v kateri je sodelovalo 54 onkoloških centrov med katerimi tudi Onkološki inštitut v Ljubljani. The 3-year disease-free survival rate for patients with locally advanced rectal cancer is currently approximately 50%. Standard treatment for patients at high risk of local and/or systemic disease recurrence includes preoperative radiotherapy following a long protocol (5 weeks) in combination with chemotherapy (neoadjuvant chemoradiotherapy). Neoadjuvant chemoradiotherapy has been shown to improve local control but not to affect survival. Systemic recurrences remain a major problem in locally advanced rectal cancer. The RAPIDO (Rectal cancer And Preoperative Induction therapy followed by Dedicated Operation - RAPIDO) study was designed and implemented with the aim of reducing distant metastases without jeopardizing locoregional control by using radiotherapy after a short regimen, followed by chemotherapy and delayed surgery. It was a multicenter, international phase 3 study in which 54 oncology centers participated, including the Oncology Institute in Ljubljana. rak danke onkološko zdravljenje klinične študije rectal cancer the RAPIDO study true false true Onkološki inštitut Slovenski jezik Angleški jezik by Author Neznano 2023-01-16 09:39:47 2023-01-16 09:39:47 2023-02-18 03:34:44 0000-00-00 00:00:00 2022 0 Ljubljana 0 Nasl. z nasl. zaslona; Opis vira z dne 29. 12. 2022; Str. 103-105 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.3 135702019 133694211 RAZ_Edhemovic_Ibrahim_2022.pdf RAZ_Edhemovic_Ibrahim_2022.pdf 1 1A39D397103801B68B62BF3693677F56 36c40074af403cd45254e41216e36bc4033b9ea24142eadc57255226adc6cd9a d4245b23-9579-11ed-b359-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=21344 Onkološki inštitut Ljubljana 0 0 0