20.500.12556/DiRROS-15465 Real-world testing practices, treatment patterns and clinical outcomes in patients from Central Eastern Europe with EGFR-mutated advanced non-small cell lung cancer a retrospective chart review study (REFLECT) Real-world testing practices, treatment patterns and clinical outcomes in patients from Central Eastern Europe with EGFR-mutated advanced non-small cell lung cancer: a retrospective chart review study (REFLECT) The targeted therapy with tyrosine kinase inhibitors (TKIs) against the epidermal growth factor receptor mutation (EGFRm) in advanced non-small cell lung cancer (NSCLC) changed the treatment paradigm. REFLECT study (NCT04031898) explored EGFR/T790M testing and treatment patterns in EGFRm NSCLC patients receiving first- or second-generation (1G/2G) EGFR TKIs as front-line (1L) in eight countries. Pooled data from Central Eastern Europe (CEE) countries from this study (Bulgaria, Poland, Romania, Slovenia) are presented here. This physician-led chart review study was conducted in patients with confirmed-EGFRm NSCLC initiating 1L 1G/2G EGFR TKIs between 2015–2018. The CEE cohort included 389 patients receiving 1L erlotinib (37%), afatinib (34%), and gefitinib (29%). Overall, 320 (82%) patients discontinued 1L, and 298 (77%) progression events were registered. Median progression free survival on 1L TKIs was 14.0 (95% CI: 12.6–15.6) months. Median overall survival from 1L start was 26.6 (95% CI: 24.1–29.0) months. Attrition rate between 1L and next line was 30%. Among patients with 1L progression, 200 (67%) were tested for T790M and 58% were positive. This first CEE analysis of treatments and outcomes in EGFRm NSCLC patients highlights the importance of using the most efficacious therapies currently available in 1L to reduce attrition and improve patient outcomes. lung neoplasms non-small cell lung carcinoma Eastern Europe real-world study REFLECT study epidermal growth factor receptor lung cancer pljučni rak pljučne novotvorbe nedrobnocelični karcinom pljuč Vzhodna Evropa klinične študije raziskava REFLECT receptor epidermalnega rastnega faktorja rak pljuč true false true MDPI Angleški jezik Slovenski jezik Europe, Eastern; Vzhodna Evropa; © 2022 by the authors Neznano 2022-09-09 15:02:04 2022-09-09 15:02:06 2022-09-10 03:34:17 0000-00-00 00:00:00 2022 0 Švica 0 Soavtorica iz Slovenije: Nina Turnšek str. 5833-5845 iss. 8 Vol. 29 Aug. 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 2022-08-11 2022-08-17 616.2 1198-0052 10.3390/curroncol29080460 119484931 https://www.mdpi.com/1718-7729/29/8/460/pdf?version=1660898466 0 b76a8ce3-302f-11ed-bea5-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=20468 Univerzitetna klinika za pljučne bolezni in alergijo Golnik Onkološki inštitut Ljubljana 0 0 0