20.500.12556/DiRROS-15455 Neuroendocrine carcinoma of the larynx and pharynx a clinical and histopathological study Neuroendocrine carcinomas (NECs) of the head and neck are rare and the experience scanty. The Cancer Registry of Slovenia database was used to identify cases of laryngeal and pharyngeal NECs diagnosed between 1995%2020. Biopsies were analyzed for the expression of standard neuroendocrine markers (synaptophysin, chromogranin, CD56), INSM1, Ki-67, p16, and PD-L1 (using the combined positive score, CPS). In situ hybridization for human papillomavirus (HPV) and Epstein%Barr virus (EBV) was performed. Twenty patients (larynx, 12; pharynx, 8) were identified. One tumor was well differentiated (WD), five were moderately differentiated (MD), and 14 were poorly differentiated (PD). Disease control was achieved solely by surgery in 4/4 MD/PD T1-2N0-1 tumors. Eight patients died of the disease, seven of which were due to distant metastases. All three traditional markers were positive in 11/17 NECs and the INSM1 marker in all 20 tumors. Two of fourteen p16-positive tumors were HPV-positive, but all three nasopharyngeal NECs were EBV-negative. Three tumors had CPSs % 1. In conclusion, INSM1 was confirmed to be a reliable marker of neuroendocrine differentiation. Except in WD and early-stage MD/PD tumors, aggressive multimodal therapy is needed; the optimal systemic therapy remains to be determined. p16, HPV, and EBV seem to bear no prognostic information. electrochemotherapy head and neck cancer neuroendocrinic carcinoma elektrokemoterapija rak glave in vratu nevroendokrini rak true false true MDPI AG Angleški jezik Slovenski jezik by Authors Neznano 2022-09-07 03:37:32 2022-09-07 08:07:18 2022-09-08 03:36:07 0000-00-00 00:00:00 2021 0 Basel 0 Nasl. z nasl. zaslona; Opis vira z dne 3. 10. 2021; str. [1-16] no. 19 Vol. 13 2021 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 2021-09-27 615.82/.84 2072-6694 79949315 https://www.mdpi.com/2072-6694/13/19/4813 1 e35f1c5f-2e3c-11ed-bea5-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=20441 RAZ_Strojan_Primoz_2021.pdf RAZ_Strojan_Primoz_2021.pdf 1 037DF31D4F05DA593B4B3B77E0C26075 588f81748a6d6166bd4a8726415e8d7e767db9b6fd974e921f2415b1e2ead3f6 30ab7cac-2e63-11ed-bea5-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=20448 Onkološki inštitut Ljubljana 0 0 0