20.500.12556/DiRROS-15409 Risk factors for systemic reactions in typical cold urticaria results from the COLD-CE study Risk factors for systemic reactions in typical cold urticaria: results from the COLD-CE study Background. Cold urticaria (ColdU), i.e. the occurrence of wheals or angioedema in response to cold exposure, is classified into typical and atypical forms. The diagnosis of typical ColdU relies on whealing in response to local cold stimulation testing (CST). It can also manifest with cold-induced anaphylaxis (ColdA). We aimed to determine risk factors for ColdA in typical ColdU. Methods. An international, cross-sectional study COLD-CE was carried out at 32 urticaria centers of reference and excellence (UCAREs). Detailed history was taken and CST with an ice cube and/or TempTest® performed. ColdA was defined as an acute cold-induced involvement of the skin and/or visible mucosal tissue and at least one of: cardiovascular manifestations, difficulty breathing, or gastrointestinal symptoms. Results. Of 551 ColdU patients, 75% (n=412) had a positive CST and ColdA occurred in 37% (n=151) of the latter. Cold-induced generalized wheals, angioedema, acral swelling, oropharyngeal/laryngeal symptoms, and itch of earlobes were identified as signs/symptoms of severe disease. ColdA was most commonly provoked by complete cold water immersion and ColdA caused by cold air was more common in countries with a warmer climate. Ten percent (n=40) of typical ColdU patients had a concomitant chronic spontaneous urticaria (CSU). They had a lower frequency of ColdA than those without CSU (4% vs 39%, p=0.003). We identified the following risk factors for cardiovascular manifestations: previous systemic reaction to a Hymenoptera sting, angioedema, oropharyngeal/laryngeal symptoms, and itchy earlobes. Conclusion. ColdA is common in typical ColdU. High-risk patients require education about their condition and how to use an adrenaline autoinjector. urticaria risk factors epinephrine - therapeutic use self administration intramuscular injections - methods cold urticaria systemic reactions adrenaline autoinjector koprivnica urtikarija dejavniki tveganja adrenalin - terapevtska raba avtoadministracija intramuskularne injekcije - metode urtikarija zaradi mraza sistemske reakcije avtoinjektor adrenalina true false true Wiley Angleški jezik Slovenski jezik © 2021 The Authors Neznano 2022-08-31 14:35:47 2022-08-31 14:35:47 2022-09-01 03:34:35 0000-00-00 00:00:00 2022 0 Velika Britanija 0 Nasl. z nasl. zaslona; Soavtorji iz Slovenije: Mitja Košnik, Dejan Dinevski, Jovan Miljković; Opis vira z dne 6. 12. 2021; str. 2185-2199 iss. 7 Vol. 77 Jul. 2022 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 2021-11-20 2021-12-04 616-097 1398-9995 10.1111/all.15194 88071683 https://onlinelibrary.wiley.com/doi/10.1111/all.15194 Dostopno z geslom 1 717cd9f1-2929-11ed-b6b8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=20366 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0