20.500.12556/DiRROS-15227 Solid cancer patients achieve adequate immunogenicity and low rate of severe adverse events after SARS-CoV-2 vaccination Background: SARS-CoV-2 vaccination in cancer patients is crucial to prevent severe COVID-19 disease course. Methods: This study assessed immunogenicity of cancer patients on active treatment receiving mRNA-based SARS-CoV-2 vaccine by detection of anti-SARS-CoV-2 S1 IgG antibodies in serum, before, after the first and second doses and 3 months after a complete primary course of vaccination. Results were compared with healthy controls. Results: Of 112 patients, the seroconversion rate was 96%. A significant reduction in antibody levels was observed 3 months after vaccination in patients receiving immune checkpoint inhibitors versus control participants (p < 0.001). Adverse events were mostly mild. Conclusion: Immunogenicity after mRNA-based vaccine in cancer patients is adequate but influenced by the type of anticancer therapy. Antibody levels decline after 3 months, and thus a third vaccination is warranted. onkološko zdravljenje imunogenost osnovno cepljenje mRNA čvrsti tumorji anticancer treatment immunogenicity mRNA-based vaccination solid cancer true false true Future Medicine Angleški jezik Ni določen (C) 2022 The Authors Neznano 2022-06-24 13:02:16 2022-06-24 13:02:17 2022-08-21 03:36:10 0000-00-00 00:00:00 2022 0 Velika Britanija 0 Soavtorji: Urška Bidovec-Stojković, Katja Mohorčič, Loredana Mrak, Nina Fokter Dovnik, Marija Ivanović, Maja Ravnik, Marina Čaks, Erik Škof, Jerneja Debeljak, Peter Korošec & Matija Rijavec; str. [1-10] iss. Vol. 2022 0000-00-00 PostprintKoncna VTisku NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 1479-6694 10.2217/fon-2022-0148 111378179 RAZ_Janzic_Urska_i2022.pdf RAZ_Janzic_Urska_i2022.pdf 1 CA4038977033DC2EEB666EA80845FD83 fd7c97cc3c3c7d1990247f76d517e04964ec0f9b1fad56b205f3ed79763c96dd f21d709d-17b6-11ed-b6b8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=19976 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0