20.500.12556/DiRROS-15227
Solid cancer patients achieve adequate immunogenicity and low rate of severe adverse events after SARS-CoV-2 vaccination
Background: SARS-CoV-2 vaccination in cancer patients is crucial to prevent severe COVID-19 disease course. Methods: This study assessed immunogenicity of cancer patients on active treatment receiving mRNA-based SARS-CoV-2 vaccine by detection of anti-SARS-CoV-2 S1 IgG antibodies in serum, before, after the first and second doses and 3 months after a complete primary course of vaccination. Results were compared with healthy controls. Results: Of 112 patients, the seroconversion rate was 96%. A significant reduction in antibody levels was observed 3 months after vaccination in patients receiving immune checkpoint inhibitors versus control participants (p < 0.001). Adverse events were mostly mild. Conclusion: Immunogenicity after mRNA-based vaccine in cancer patients is adequate but influenced by the type of anticancer therapy. Antibody levels decline after 3 months, and thus a third vaccination is warranted.
onkološko zdravljenje
imunogenost
osnovno cepljenje mRNA
čvrsti tumorji
anticancer treatment
immunogenicity
mRNA-based vaccination
solid cancer
true
false
true
Future Medicine
Angleški jezik
Ni določen
(C) 2022 The Authors
Neznano
2022-06-24 13:02:16
2022-06-24 13:02:17
2022-08-21 03:36:10
0000-00-00 00:00:00
2022
0
Velika Britanija
0
Soavtorji: Urška Bidovec-Stojković, Katja Mohorčič, Loredana Mrak, Nina Fokter Dovnik, Marija Ivanović, Maja Ravnik, Marina Čaks, Erik Škof, Jerneja Debeljak, Peter Korošec & Matija Rijavec;
str. [1-10]
iss.
Vol.
2022
0000-00-00
PostprintKoncna
VTisku
NiDoloceno
0000-00-00
0000-00-00
0000-00-00
616-006
1479-6694
10.2217/fon-2022-0148
111378179
RAZ_Janzic_Urska_i2022.pdf
RAZ_Janzic_Urska_i2022.pdf
1
CA4038977033DC2EEB666EA80845FD83
fd7c97cc3c3c7d1990247f76d517e04964ec0f9b1fad56b205f3ed79763c96dd
f21d709d-17b6-11ed-b6b8-001a4af901a5
https://dirros.openscience.si/Dokument.php?lang=slv&id=19976
Univerzitetna klinika za pljučne bolezni in alergijo Golnik
0
0
0