20.500.12556/DiRROS-15175 Brain dynamics underlying preserved cycling ability in patients with Parkinson’s disease and freezing of gait Parkinson’s disease (PD) is generally associated with abnormally increased beta band oscillations in the cortico-basal ganglia loop during walking. PD patients with freezing of gait (FOG) exhibit a more distinct, prolonged narrow band of beta oscillations that are locked to the initiation of movement at ∼18 Hz. Upon initiation of cycling movements, this oscillation has been reported to be weaker and rather brief in duration. Due to the suppression of the overall beta band power during cycling and its continuous nature of the movement, cycling is considered to be less demanding for cortical networks compared to walking, including reduced need for sensorimotor processing, and thus unimpaired continuous cycling motion. Furthermore, cycling has been considered one of the most efficient non-pharmacological therapies with an influence on the subthalamic nucleus (STN) beta rhythms implicative of the deep brain stimulation effects. In the current review, we provide an overview of the currently available studies and discuss the underlying mechanism of preserved cycling ability in relation to the FOG in PD patients. The mechanisms are presented in detail using a graphical scheme comparing cortical oscillations during walking and cycling in PD. gait freezing of gait Parkinson's disease cycling cortical oscillations beta band zamrznitev hoje Parkinsonova bolezen kolesarjenje Kortikalne oscilacije beta območje true false true Angleški jezik Ni določen © 2022 Licen, Rakusa, Bohnen, Manganotti and Marusic Neznano 2022-06-21 09:09:58 2022-06-21 09:10:00 2022-09-13 10:59:04 0000-00-00 00:00:00 2022 0 0 Nasl. z nasl. zaslona; Soavtorji: Martin Rakusa, Nicolaas I. Bohnen, Paolo Manganotti, Uros Marusic; Opis vira z dne 20. 6. 2022; str. 1-6 art. 847703 Vol. 13 Jun. 2022 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 2022-05-20 2022-06-16 616.858:796.01 1664-1078 10.3389/fpsyg.2022.847703 112226563 ZRSKP_Licen_Teja_i2022.pdf ZRSKP_Licen_Teja_i2022.pdf 1 8C43B400518986ED4FE2FFA813FD40C5 d7c40e2d09af85d2db09ee03d2b0add9c210733286384d555911252518cb9175 eea67de1-17b6-11ed-b6b8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=19872 https://doi.org/10.3389/fpsyg.2022.847703 1 https://dirros.openscience.si/Dokument.php?lang=slv&id=19873 Znanstveno-raziskovalno središče Koper / Centro di Ricerche Scientifiche Capodistria 0 0 0