20.500.12556/DiRROS-15113 Does cognitive training improve mobility, enhance cognition, and promote neural activation? A close inter-relationship between mobility and cognition is reported in older adults, with improvements in gait performance noticeable after cognitive remediation in frail individuals. The aim of this study was to evaluate the efficacy of computerized cognitive training (CCT) on mobility in healthy, independently living older adults, and to determine whether CCT is associated with changes in neural activation for mobility-related brain processes. Using a randomized single-blind control design, sixty-three non-demented adults age 60 y and older (mean age = 67 y; 76% female, mean Montreal Cognitive Assessment [MoCA] score = 27) were recruited from a local Senior Activity Center. Participants were randomly assigned to either a 2-month CCT program (8 weeks, 3x/week, 40 min/session) or a wait-list control group. Primary outcome was self-selected gait speed during single- and dual-task walking. Secondary outcome was executive function on Trail Making Test (TMT), Part B. Neural activity was assessed via electroencephalography/event-related potentials (EEG/ERPs) targeting lower-limb performance. Results from a linear mixed effect model, adjusted for baseline MoCA score, age, gender, and study completion revealed that compared to controls, CCT improved gait speed during the dual-task (p = 0.008) but not during the single-task walking condition (p = 0.057). CCT also improved executive function (p = 0.024). Further, shorter foot reaction time responses (p = 0.019) were found with enhanced neural activation over sensorimotor areas, with shorter ERP latencies during the P2 component (p = 0.008) and enhanced motor responses (p = 0.009) also evident in the CCT group after the intervention. Overall, the electrophysiological findings suggest possible neural adaptations that could explain improvements in mobility and executive functions associated with CCT in healthy older adults. visual evoked potentials motor-related cortical potentials executive control cognitive-motor brain networks healthy aging sensorimotor integration functional mobility vidni evocirani potenciali motorični potenciali izvršilni nadzor kognitivno-motorične možganske mreže zdravo staranje senzomotorična integracija funkcionalna mobilnost true false true Angleški jezik Ni določen 2022 Marusic, Verghese and Mahone Neznano 2022-05-24 15:14:50 2022-05-24 15:14:52 2022-09-07 11:20:45 0000-00-00 00:00:00 2022 0 0 Nasl. z nasl. zaslona; Opis vira z dne 24. 5. 2022; str. 1-13 art. 845825 Vol. 14 May 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 2022-04-21 2022-05-23 796.012.23:159.955 1663-4365 10.3389/fnagi.2022.845825 109008899 ZRSKP_Marusic_Uros_i2022.pdf ZRSKP_Marusic_Uros_i2022.pdf 1 0D05C64F16FBB840923C6076EFB3448D b3adc172cdd8a39f4487515bd3fc6e36b8b4d22847737e25960959c91c0fd86a ea8d8e55-17b6-11ed-b6b8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=19740 https://doi.org/10.3389/fnagi.2022.845825 1 https://dirros.openscience.si/Dokument.php?lang=slv&id=19739 Znanstveno-raziskovalno središče Koper / Centro di Ricerche Scientifiche Capodistria 0 0 0