20.500.12556/DiRROS-15102 Dietary acid load but not Mediterranean diet adherence score is associated with metabolic and cardiovascular health state : ǂa ǂpopulation observational study from Northern Italy Diet plays a pivotal role in shaping the trajectory of chronic diseases. In this regard, the Mediterranean diet has been widely shown to exert beneficial effects on cardiometabolic health. On the contrary, the Western diet, which has also been reported to be an acidogenic dietary pattern, elicits detrimental effects on both metabolic and cardiovascular (CV) health. However, the role of dietary acid load (DAL) as a predictor of cardiometabolic prognosis remains to be elucidated. Thus, this study aims to compare Mediterranean diet adherence (MDA) and DAL focusing on their relationship with metabolic and CV prognosis. A total of 448 individuals aged 55–80 years were grouped depending on their MDA, assessed using food frequency questionnaires, or DAL, evaluated using potential renal load acid (PRAL) and net-endogenous acid production (NEAP). Study participants underwent anthropometric and biochemical measurements. The metabolic syndrome (MetS) prevalence was evaluated according to the National Cholesterol Education Program-Adult Treatment Panel III. Finally, the CV risk was evaluated using three independent algorithms: atherosclerotic cardiovascular disease (ASCVD), European Systematic COronary Risk Evaluation (SCORE), and Cuore risk scores. Mediterranean diet adherence was negatively associated with PRAL and NEAP. Individuals in the higher MDA tertile group had higher HDL cholesterol as well as lower homeostasis model assessment index (HOMA-IR) and fat mass relative to the lowest MDA tertile. However, in the high-MDA tertile group, there was neither a significantly lower MetS prevalence nor CV risk. Instead, both the MetS prevalence and CV risk were higher in individuals in the higher acid PRAL quartile relative to the lower alkaline PRAL quartile. Dietary acid load, especially assessed using PRAL but not MDA, was associated with indices of metabolic and CV prognosis. Thus, DAL assessed by 24-h dietary recalls may represent a better predictor of cardiometabolic health if compared to MDA evaluated using food frequency questionnaires. Mediterranean diet dietary acid load alkaline diet acidic diet metabolic syndrome cradiovascular risk score mediteranska dieta prehranski vnos kislin alkalna dieta kislinska dieta metabolni sindrom true false true Angleški jezik Ni določen © 2022 Sanz, Sergi, Colombari, Capatti, Situlin, Biolo, Di Girolamo, Lazzer, Šimunič, Pišot and Passaro Neznano 2022-05-19 09:48:01 2022-05-19 09:48:03 2022-09-07 11:11:10 0000-00-00 00:00:00 2022 0 0 Nasl. z nasl. zaslona; Soavtorji: Domenico Sergi, Simona Colombari, Eleonora Capatti, Roberta Situlin, Gianni Biolo, Filippo Giorgio Di Girolamo, Stefano Lazzer, Boštjan Šimunič, Rado Pišot, Angelina Passaro; Opis vira z dne 19. 5. 2022; str. 1-11 art. 828587 Vol. 9 Apr. 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 2022-03-14 2022-04-26 613.2:616.1 2296-861X 10.3389/fnut.2022.828587 108322563 ZRSKP_Sanz_Juana_Maria_i2022.pdf ZRSKP_Sanz_Juana_Maria_i2022.pdf 1 2783B880678778D9B871801BB7A648AE 78937ae75bd8e8f82290004ef72bf87f97cb568fd27cd8c6a1a00e69e35c92e1 ea0ccdf9-17b6-11ed-b6b8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=19724 https://doi.org/10.3389/fnut.2022.828587 1 https://dirros.openscience.si/Dokument.php?lang=slv&id=19722 Znanstveno-raziskovalno središče Koper / Centro di Ricerche Scientifiche Capodistria 0 0 0