20.500.12556/DiRROS-13711 Immunological outcomes of allergen-specific immunotherapy in food allergy IgE-mediated food allergies are caused by adverse immunologic responses to food proteins. Allergic reactions may present locally in different tissues such as skin, gastrointestinal and respiratory tract and may result is systemic life-threatening reactions. During the last decades, the prevalence of food allergies has significantly increased throughout the world, and considerable efforts have been made to develop curative therapies. Food allergen immunotherapy is a promising therapeutic approach for food allergies that is based on the administration of increasing doses of culprit food extracts, or purified, and sometime modified food allergens. Different routes of administration for food allergen immunotherapy including oral, sublingual, epicutaneous and subcutaneous regimens are being evaluated. Although a wealth of data from clinical food allergen immunotherapy trials has been obtained, a lack of consistency in assessed clinical and immunological outcome measures presents a major hurdle for evaluating these new treatments. Coordinated efforts are needed to establish standardized outcome measures to be applied in food allergy immunotherapy studies, allowing for better harmonization of data and setting the standards for the future research. Several immunological parameters have been measured in food allergen immunotherapy, including allergen-specific immunoglobulin levels, basophil activation, cytokines, and other soluble biomarkers, T cell and B cell responses and skin prick tests. In this review we discuss different immunological parameters and assess their applicability as potential outcome measures for food allergen immunotherapy that may be included in such a standardized set of outcome measures. food hypersensitivity food intolerance immunotherapy immunology food allergy food allergens oral immunotherapy preobčutljivost za hrano intoleranca na hrano imunoterapija imunologija alergija za hrano prehranski alergeni oralna imunoterapija true false true Frontiers Research Foundation Angleški jezik Ni določen © 2020 Schoos, Bullens, Chawes, Costa, De Vlieger, DunnGalvin, Epstein, Garssen, Hilger, Knipping, Kuehn, Mijakoski, Munblit, Nekliudov, Ozdemir, Patient, Peroni, Stoleski, Stylianou, Tukalj, Verhoeckx, Zidarn and van de Veen. Neznano 2021-02-15 10:40:37 2021-02-15 10:40:40 2022-08-19 03:36:13 0000-00-00 00:00:00 2020 0 Švica 0 Nasl. z nasl. zaslona; Soavtorica iz Slovenije: Mihaela Zidarn; Opis vira z dne 9. 2. 2021; str. 1-20 3 Nov. 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-097 1664-3224 10.3389/fimmu.2020.568598 50624515 30774233 RAZ_Schoos_Anne-Marie_Malby_i2020.pdf RAZ_Schoos_Anne-Marie_Malby_i2020.pdf 1 F110CA96046F80FF1455534B3C7FE9AE 8b081db2350ce69fad92b317e3509e187ff9fffbf943fbc1e228b2b4b4ce420e 83fa059d-17b6-11ed-b6b8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=17142 RAZ_Schoos_Anne-Marie_Malby_i2020.xlsx RAZ_Schoos_Anne-Marie_Malby_i2020.xlsx 1 2BC5E6957541C560AC57FA365B2AE087 3f557c9e24dfd4d82f219e216771a2fa33a0774b5e16337dc33d57985ebbda5e 840d7e48-17b6-11ed-b6b8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=17143 https://www.frontiersin.org/articles/10.3389/fimmu.2020.568598/full#supplementary-material 1 https://dirros.openscience.si/Dokument.php?lang=slv&id=16751 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0