20.500.12556/DiRROS-13700 Morphologic and molecular classification of lung neuroendocrine neoplasms Neuroendocrine neoplasms (NENs) of the lung encompass neuroendocrine tumors (NETs) composed of typical (TC) and atypical (AC) carcinoids and full-fledged carcinomas (NECs) inclusive of large cell neuroendocrine carcinoma (LCNEC) and small cell carcinoma (SCLC). NETs and NECs are thought to represent distinct and separate lesions with neither molecular overlap nor common developmental continuum. Two perspectives were addressed regarding the morphologic and molecular classification of lung NENs: (i) a supervised approach by browsing the traditional classification, the relevant gene alterations, and their clinical implications; and (ii) an unsupervised approach, by reappraising neoplasms according to risk factors and natural history of disease to construct an interpretation model relied on biological data. We herein emphasize lights and shadows of the current classification of lung NENs and provide an alternative outlook on these tumors focused on what we currently know about the biological determinants and the natural history of disease. neuroendocrine tumors lung neoplasms carcinoma lung tumors morphologic classification molecular classification nevroendokrini tumorji pljučne novotvorbe karcinom pljučni tumorji morfološka klasifikacija molekularna klasifikacija true false true Springer Nature Angleški jezik Ni določen (c) The Author(s) 2021 Neznano 2021-02-02 13:53:11 2021-02-02 13:53:12 2022-08-19 03:36:10 0000-00-00 00:00:00 2021 0 Nemčija 0 Nasl. z nasl. zaslona; Soavtor iz Slovenije: Izidor Kern; Opis vira z dne 1. 2. 2021; str. [1-15] iss. Vol. 478 2021 0000-00-00 PostprintKoncna VTisku NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 1432-2307 10.1007/s00428-020-03015-z 49608195 2517524 RAZ_Metovic_Jasna_i2021.pdf RAZ_Metovic_Jasna_i2021.pdf 1 E31912859DC921E02096FD7F44CCF722 5d82170524f8d5d26417ff7fd7148730db16f80a6471d7b1405788e3bd27a873 84334752-17b6-11ed-b6b8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=17145 https://link.springer.com/content/pdf/10.1007/s00428-020-03015-z.pdf 1 https://dirros.openscience.si/Dokument.php?lang=slv&id=16731 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0