Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies
There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR[gamma]:Peroxisome proliferator-activated receptor, NF[kappa]B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2[alpha]:Elongation initiation factor 2[alpha]). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
© The Author(s) 2020
2020
2021-01-25 14:34:16
1033
Covid-19, SARS-CoV-2, food, insulin resistance, obesity, Nrf2, nutrients, TRPA1
covid-19, SARS-CoV-2, hrana, odpornost proti inzulinu, debelost, Nrf2, hranila, TRPA1
Springer Nature
Jean
Bousquet
70
Jean-Paul
Cristol
70
Wienczyslawa
Czarlewski
70
Josep M.
Antò i Boquè
70
Adrian
Martineau
70
Tari
Haahtela
70
Susana C.
Fonseca
70
Guido
Iaccarino
70
Hubert
Blain
70
Alessandro
Fiocchi
70
Nisera
Bajrović
70
Natalija
Edelbaher
70
Maja
Jošt
70
Peter
Kopač
70
Anja
Koren
70
Mitja
Košnik
70
Karmen
Kramer Vrščaj
70
Samo
Kreft
70
Nika
Lalek
70
Bojan
Madjar
70
Tonka
Poplas-Susič
70
Irma
Rozman Sinur
70
Tanja
Soklič
70
Katja
Triller Vadnal
70
Nadja
Triller
70
Jure
Urbančič
70
Mihaela
Zidarn
70
UDK
4
616.9
ISSN pri članku
9
2045-7022
DOI
15
10.1186/s13601-020-00362-7
COBISS_ID
3
47724291
OceCobissID
13
31507929
s13601-020-00362-7.pdf
1687536
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2021-01-25 14:34:19