20.500.12556/DiRROS-12921 Inhaled therapies in patients with moderate COPD in clinical practice : current thinking COPD is a complex, heterogeneous condition. Even in the early clinical stages, COPD carries a significant burden, with breathlessness frequently leading to a reduction in exercise capacity and changes that correlate with long-term patient outcomes and mortality. Implementation of an effective management strategy is required to reduce symptoms, preserve lung function, quality of life, and exercise capacity, and prevent exacerbations. However, current clinical practice frequently differs from published guidelines on the management of COPD. This review focuses on the current scientific evidence and expert opinion on the management of moderate COPD: the symptoms arising from moderate airflow obstruction and the burden these symptoms impose, how physical activity can improve disease outcomes, the benefits of dual bronchodilation in COPD, and the limited evidence for the benefits of inhaled corticosteroids in this disease. We emphasize the importance of maximizing bronchodilation in COPD with inhaled dual-bronchodilator treatment, enhancing patient-related outcomes, and enabling the withdrawal of inhaled corticosteroids in COPD in well-defined patient groups. dual bronchodilation inhaled corticosteroid LAMA LABA tiotropium anticholinergic kronična obstruktivna pljučna bolezen pljučne bolezni diagnostika kajenje spirometrija true false true Dove Medical Press Angleški jezik Ni določen © 2018 Ariel et al. Neznano 2020-12-17 09:23:42 2020-12-17 09:23:42 2022-08-19 03:35:41 0000-00-00 00:00:00 2018 0 Velika Britanija 0 Soavtorji: Alan Altraja, Andrey Belevskiy, Piotr W Boros, Edvardas Danila, Matjaz Fležar, Vladimir Koblizek, Zvi G Fridlender,Kosta Kostov, Alvils Krams, Branislava Milenkovic, Attila Somfay, Ruzena Tkacova, Neven Tudoric, Ruxandra Ulmeanu, Arschang Valipour; Nasl. z nasl. zaslona; Opis vira z dne 23. 1. 2018; str. 45-56 Vol. 13 2018 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.24-007.272 1178-2005 10.2147/COPD.S145573 293446912 512411449 RAZ_Amnon_Ariel_i2018.pdf RAZ_Amnon_Ariel_i2018.pdf 1 B4CFF1E31245EAE773EEACDDA65994F3 4dd84be6f3bdb967a11ddc2d33310cc390ce4acf5a6e1194062c4b0218e02987 846a1eb2-17b6-11ed-b6b8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=17149 https://www.dovepress.com/inhaled-therapies-in-patients-with-moderate-copd-in-clinical-practice--peer-reviewed-article-COPD 1 https://dirros.openscience.si/Dokument.php?lang=slv&id=15893 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0