20.500.12556/DiRROS-12914 GLCCI1 polymorphism rs37973 and asthma treatment response to inhaled corticosteroids Background. Asthma treatment response is highly variable and pharmacogenetic markers that predict treatment response would be one step closer to personalized treatment. GWAS studies have shown that polymorphisms GLCCI1 could be associated with asthma treatment response to inhaled corticosteroids (ICS). Materials and methods. We genotyped rs37973 of GLCCI1 in 208 adult asthma patients treated with ICS. Change in % predicted FEV1 was analysed after short-term (3 months) and after long-term (at least 3 years) treatment. Treatment success was defined as good when FEV1 decreased less than 30 ml/year. Results. After 3 months of treatment, change of % predicted FEV1 was higher in patients with GG genotype than in patients with AG+AA genotype, and this genotype dependent difference was only evident in non-smokers. Similar results were found after at least 3 years of treatment when all patients were analysed, in non-smokers and patients with atopy. Even though, no differences in treatment success (good vs. poor response) were observed when analysing the entire group of patients, genotype dependent treatment success was highly influenced by smoking and atopy. GG genotype was overrepresented in non-smokers and patients with atopy with good response. Conclusions. Rs37973 was associated with short- and long-term treatment response; however, there was a great influence of smoking and atopy on pharmacogenetic association. Furthermore, we found GG genotype to be associated with better treatment response, what is contrary to results found in GWAS. asthma -- diagnosis -- therapy pharmacogenetics genetic polymorphism smoking inhaled corticosteroids atopy GLCCI1 FEV1 rs37973 astma -- diagnostika -- terapija farmakogenetika genetski polimorfizem kajenje inhalacijski kortikosteroidi atopija true false true Esmon Publicidad Angleški jezik Španski jezik © 2018 Esmon Publicidad, S.A. Neznano 2020-12-16 17:41:34 2020-12-16 17:41:34 2022-08-19 03:35:39 0000-00-00 00:00:00 2018 0 Španija 0 Soavtorji: Žavbi M, Lopert A, Fležar M, Korošec P; Nasl. z nasl. zaslona; Opis vira z dne 21. 3. 2018; str. 165-171 iss. 3 Vol. 28 2018 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.2 1698-0808 10.18176/jiaci.0229 2048262769 524162329 http://www.jiaci.org/revistas/vol28issue3_3.pdf 1 https://dirros.openscience.si/Dokument.php?lang=slv&id=15886 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0