20.500.12556/DiRROS-12902 Important and specific role for basophils in acute allergic reactions IgE-mediated allergic reactions involve the activation of effector cells, predominantly through the high-affinity IgE receptor (FceRI) on mast cells and basophils. Although the mast cell is considered the major effector cell during acute allergic reactions, more recent studies indicate a potentially important and specific role for basophils and their migration which occurs rapidly upon allergen challenge in humans undergoing anaphylaxis. We review the evidence for a role of basophils in contributing to clinical symptoms of anaphylaxis, and discuss the possibility that basophil trafficking during anaphylaxis might be a pathogenic (to target organs) or protective (preventing degranulation in circulation) response. Finally, we examine the potential role of basophils in asthma exacerbations. Understanding the factors that regulate basophil trafficking and activation might lead to new diagnostic and therapeutic strategies in anaphylaxis and asthma. allergy and immunology basophils anaphylaxis alergija in imunologija bazofilci anafilaksija true false true John Wiley & Sons Angleški jezik Ni določen © 2018 The Authors. Neznano 2020-12-14 11:54:49 2020-12-14 11:54:50 2022-08-19 03:35:34 0000-00-00 00:00:00 2018 0 Velika Britanija 0 Soavtorji: Bernhard F. Gibbs, Matija Rijavec, Adnan Custovic and Paul J. Turner; Nasl. z nasl. zaslona; Opis vira z dne 7. 3. 2018; str. 502-512 iss. 5 Vol. 48 May 2018 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-097 1365-2222 10.1111/cea.13117 2048254577 515014681 RAZ_Korosec_Peter_i2018.pdf RAZ_Korosec_Peter_i2018.pdf 1 D14CB5AECABFAEC38A9203C1D6BC8680 7aeaa88dfb82a29729c7e11c6c284f7c90342a01966c4fb20cf6ef8cfdb1a64b 849c8e9a-17b6-11ed-b6b8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=17152 https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.13117 1 https://dirros.openscience.si/Dokument.php?lang=slv&id=15873 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0