Important and specific role for basophils in acute allergic reactions
IgE-mediated allergic reactions involve the activation of effector cells, predominantly through the high-affinity IgE receptor (FceRI) on mast cells and basophils. Although the mast cell is considered the major effector cell during acute allergic reactions, more recent studies indicate a potentially important and specific role for basophils and their migration which occurs rapidly upon allergen challenge in humans undergoing anaphylaxis. We review the evidence for a role of basophils in contributing to clinical symptoms of anaphylaxis, and discuss the possibility that basophil trafficking during anaphylaxis might be a pathogenic (to target organs) or protective (preventing degranulation in circulation) response. Finally, we examine the potential role of basophils in asthma exacerbations. Understanding the factors that regulate basophil trafficking and activation might lead to new diagnostic and therapeutic strategies in anaphylaxis and asthma.
© 2018 The Authors.
2018
2020-12-14 11:54:49
1033
allergy and immunology, basophils, anaphylaxis
alergija in imunologija, bazofilci, anafilaksija
Peter
Korošec
70
Bernhard F.
Gibbs
70
Matija
Rijavec
70
Adnan
Custovic
70
Paul J.
Turner
70
UDK
4
616-097
ISSN pri članku
9
1365-2222
DOI
15
10.1111/cea.13117
COBISS_ID
3
2048254577
OceCobissID
13
515014681
RAZ_Korosec_Peter_i2018.pdf
523278
Predstavitvena datoteka
2021-05-10 12:10:37
0
Izvorni URL
2020-12-14 11:54:52