20.500.12556/DiRROS-12788 NSCLC molecular testing in Central and Eastern European countries Background: The introduction of targeted treatments for subsets of non-small cell lung cancer (NSCLC) has highlighted the importance of accurate molecular diagnosis to determine if an actionable genetic alteration is present. Few data are available for Central and Eastern Europe (CEE) on mutation rates, testing rates, and compliance with testing guidelines. Methods: A questionnaire about molecular testing and NSCLC management was distributed to relevant specialists in nine CEE countries, and pathologists were asked to provide the results of EGFR and ALK testing over a 1-year period. Results: A very high proportion of lung cancer cases are confirmed histologically/cytologically (75-100%), and molecular testing of NSCLC samples has been established in all evaluated CEE countries in 2014. Most countries follow national or international guidelines on which patients to test for EGFR mutations and ALK rearrangements. In most centers at that time, testing was undertaken on request of the clinician rather than on the preferred reflex basis. Immunohistochemistry, followed by fluorescent in situ hybridization confirmation of positive cases, has been widely adopted for ALK testing in the region. Limited reimbursement is a significant barrier to molecular testing in the region and a disincentive to reflex testing. Multidisciplinary tumor boards are established in most of the countries and centers, with 75-100% of cases being discussed at a multidisciplinary tumor board at specialized centers. Conclusions: Molecular testing is established throughout the CEE region, but improved and unbiased reimbursement remains a major challenge for the future. Increasing the number of patients reviewed by multidisciplinary boards outside of major centers and access to targeted therapy based on the result of molecular testing are other major challenges. non-small-cell lung carcinoma molecular diagnostic techniques EGFR mutations ALK rearrangements Central Europe Eastern Europe nedrobnocelični karcinom pljuč molekularne diagnostične tehnike mutacije EGFR Srednja Evropa Vzhodna Evropa true false true Springer Nature Angleški jezik Ni določen Central Europe; Eastern Europe; Srednja Evropa; Vzhodna Evropa; © The Author(s). 2018 Neznano 2020-11-30 10:47:31 2020-11-30 10:47:34 2022-08-19 03:34:57 0000-00-00 00:00:00 2018 0 Velika Britanija 0 Soavtorji: Peter Berzinec, Luka Brcic, Tanja Cufer, Rafal Dziadziuszko, Maya Gottfried, Ilona Kovalszky, Włodzimierz Olszewski, Buge Oz, Lukas Plank in Jozsef Timar; Nasl. z nasl. zaslona; Opis vira z dne 12. 4. 2018; str. 1-8 18 2018 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 1471-2407 10.1186/s12885-018-4023-4 2048273521 2434324 RAZ_Ryska_Ales_i2018.pdf RAZ_Ryska_Ales_i2018.pdf 1 FDB6E55E6356F21AEEA0C8AC11FAE8C5 cecee6948b61fbf0616029532e3febefb3a7eed821a7ef86369d7202b975a862 8513773b-17b6-11ed-b6b8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=17160 https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-018-4023-4.pdf 1 https://dirros.openscience.si/Dokument.php?lang=slv&id=15647 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0