20.500.12556/DiRROS-12686 The clinical relevance of oliguria in the critically ill patient : analysis of a large observational database Background: Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output < 0.5 ml/kg/h) in acutely ill patients and its association with the need for renal replacement therapy (RRT) and outcome. Methods: International observational study. All adult (> 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis. Results: Of the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient-oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged-oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent-oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19%1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97%1.34], p = 0.103). Conclusions: Oliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome. critical care critical illness urine oliguria kidney renal insufficiency kidney diseases acute kidney failure mortality urine output renal replacement therapy oskrba kritično bolnih kritično stanje urin oligurija ledvica renalna insuficienca bolezni ledvic akutna ledvična odpoved umrljivost izločanje urina nadomestno zdravljenje ledvične odpovedi true false true Springer Nature Angleški jezik Ni določen © The Author(s). 2020 Neznano 2020-11-18 13:34:52 2020-11-18 13:34:53 2022-08-18 03:38:50 0000-00-00 00:00:00 2020 0 Velika Britanija 0 Nasl. z nasl. zaslona; Opis vira z dne 16. 11. 2020; Sodelavci pri raziskavi iz Slovenije: Gorazd Voga, Erik Rupnik, Lucka Kosec, Milena Kerin Povšic, Irena Osojnik, Viktorija Tomic, Andreja Sinkovic; Article no. 171; str. 1-14 Vol. 24 2020 0000-00-00 Zaloznikova NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1/.4 1466-609X 10.1186/s13054-020-02858-x 37575171 1137983 RAZ_Vincent_Jean_Louis_i2020.pdf RAZ_Vincent_Jean_Louis_i2020.pdf 1 BCA55446D4D9D1C7BAD4D2D86C5B1F13 04794280b72ec3760a19d83f2ef7ef7cf6ba0487280ebf1cc2a26a7ca2a666e9 87d9fc9c-17b6-11ed-b6b8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=17205 https://ccforum.biomedcentral.com/track/pdf/10.1186/s13054-020-02858-x.pdf 1 https://dirros.openscience.si/Dokument.php?lang=slv&id=15445 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0