20.500.12556/DiRROS-12544 Consensus clinical scoring for suspected perioperative immediate hypersensitivity reactions Background: Grading schemes for severity of suspected allergic reactions have been applied to the perioperative setting, but there is no scoring system that estimates the likelihood that the reaction is an immediate hypersensitivity reaction. Such a score would be useful in evaluating current and proposed tests for the diagnosis of suspected perioperative immediate hypersensitivity reactions and culprit agents. Methods: We conducted a Delphi consensus process involving a panel of 25 international multidisciplinary experts in suspected perioperative allergy. Items were ranked according to appropriateness (on a scale of 1-9) and consensus, which informed development of a clinical scoring system. The scoring system was assessed by comparing scores generated for a series of clinical scenarios against ratings of panel members. Supplementary scores for mast cell tryptase were generated. Results: Two rounds of the Delphi process achieved stopping criteria for all statements. From an initial 60 statements, 43 were rated appropriate (median score 7 or more) and met agreement criteria (disagreement index <0.5); these were used in the clinical scoring system. The rating of clinical scenarios supported the validity of the scoring system. Although there was variability in the interpretation of changes in mast cell tryptase by the panel, we were able to include supplementary scores for mast cell tryptase. Conclusion: We used a robust consensus development process to devise a clinical scoring system for suspected perioperative immediate hypersensitivity reactions. This will enable objectivity and uniformity in the assessment of the sensitivity of diagnostic tests. alergy and immunology anesthesia anaphylaxis drug hypersensitivity drug-related side effects and adverse reactions perioperative period surgery operative surgical procedures alergija in imunologija anestezija anafilaksija preobčutljivost za zdravila stranski in škodljivi učinki zdravil perioperativno obdobje kirurgija operativni kirurški postopki true false true Elsevier Angleški jezik Ni določen © 2019 British Journal of Anaesthesia Neznano 2020-10-09 14:41:51 2020-10-09 14:41:51 2022-08-18 03:38:02 0000-00-00 00:00:00 2019 0 Velika Britanija 0 Soavtor iz Slovenije: P. Kopac; Nasl. z nasl. zaslona; Opis vira z dne 4. 6. 2019; str. e29-e37 iss. 1 Vol. 123 Jul. 2019 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-097 1471-6771 10.1016/j.bja.2019.02.029 2048509297 515369241 https://bjanaesthesia.org/article/S0007-0912(19)30191-6/fulltext 1 https://dirros.openscience.si/Dokument.php?lang=slv&id=15245 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0