20.500.12556/DiRROS-12301 Pulmonary pathology and COVID-19 : lessons from autopsy : the experience of European pulmonary pathologists Since its initial recognition in December 2019, Coronavirus disease 19 (COVID-19) has quickly spread to a pandemic infectious disease. The causative agent has been recognized as a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily affecting the respiratory tract. To date, no vaccines are available nor any specific treatment. To limit the number of infections, strict directives have been issued by governments that have been translated into equally rigorous guidelines notably for post-mortem examinations by international and national scientific societies. The recommendations for biosafety control required during specimen collection and handling have strongly limited the practice of autopsies of the COVID-19 patients to a few adequate laboratories. A full pathological examination has always been considered an important tool to better understand the pathophysiology of diseases, especially when the knowledge of an emerging disorder is limited and the impact on the healthcare system is significant. The first evidence of diffuse alveolar damage in the context of an acute respiratory distress syndrome has now been joined by the latest findings that report a more complex scenario in COVID-19, including a vascular involvement and a wide spectrum of associated pathologies. Ancillary tools such as electron microscopy and molecular biology used on autoptic tissue samples from autopsy are also significantly contributing to confirm and/or identify new aspects useful for a deeper knowledge of the pathogenetic mechanisms. This article will review and summarize the pathological findings described in COVID-19 until now, chiefly focusing on the respiratory tract, highlighting the importance of autopsy towards a better knowledge of this disease. COVID-19 SARS-CoV-2 autopsy lung pandemic covid-19 SARS-CoV-2 obdukcija pljuča pandemija true false true Springer Nature Angleški jezik Ni določen The Author(s) 2020 Neznano 2020-07-31 12:46:45 2020-07-31 12:46:45 2022-08-18 03:36:31 0000-00-00 00:00:00 2020 0 Nemčija 0 Nasl. z nasl. zaslona; Soavtor iz Slovenije: Izidor Kern; Opis vira z dne 29. 7. 2020; str. [1-14] iss. Vol. 477 2020 0000-00-00 PostprintKoncna VTisku NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.2 1432-2307 10.1007/s00428-020-02886-6 23930627 2517524 RAZ_Calabrese_Fiorella_i2020.pdf RAZ_Calabrese_Fiorella_i2020.pdf 1 256373B8D6A083C6B61D8B373489EFD4 d84cd1a599674e5c218ef078ef902aa3fa2dad7adcd1717b02412b598424f41a 8e8e91e6-17b6-11ed-b6b8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=17324 https://link.springer.com/content/pdf/10.1007/s00428-020-02886-6.pdf 1 https://dirros.openscience.si/Dokument.php?lang=slv&id=14825 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0