20.500.12556/DiRROS-12196 Access to novel drugs for non-small cell lung cancer in Central and Southeastern Europe : a Central European Cooperative Oncology Group analysis Background. Treatment of non-small cell lung cancer (NSCLC) improved substantially in the last decades. Novel targeted and immune-oncologic drugs were introduced into routine treatment. Despite accelerated development and subsequent drug registrations by the European Medicinal Agency (EMA), novel drugs for NSCLC are poorly accessible in Central and Eastern European (CEE) countries. Material and Methods. The Central European Cooperative Oncology Group conducted a survey among experts from 10 CEE countries to provide an overview on the availability of novel drugs for NSCLC and time from registration to reimbursement decision in their countries. Results. Although first-generation epidermal growth factor receptor tyrosine kinase inhibitors were reimbursed and available in all countries, for other registered therapies - even for ALK inhibitors and checkpoint inhibitors in first-line - there were apparent gaps in availability and/or reimbursement. There was a trend for better availability of drugs with longer time from EMA marketing authorization. Substantial differences in access to novel drugs among CEE countries were observed. In general, the availability of drugs is not in accordance with the Magnitude of Clinical Benefit Scale (MCBS), as defined by the European Society for Medical Oncology (ESMO). Time spans between drug registrations and national decisions on reimbursement vary greatly, from less than 3 months in one country to more than 1 year in the majority of countries. Conclusion. The access to novel drugs for NSCLC in CEE countries is suboptimal. To enable access to the most effective compounds within the shortest possible time, reimbursement decisions should be faster and ESMO MCBS should be incorporated into decision making. non-small cell lung cancer treatment novel drugs Central Europe Southeastern Europe nedrobnocelični rak pljuč zdravljenje nova zdravila Srednja Evropa Jugovzhodna Evropa true false true Wiley Periodicals, Inc. on behalf of AlphaMed Press Angleški jezik Ni določen © 2019 The Authors Neznano 2020-07-24 13:29:54 2020-07-24 13:29:54 2022-08-18 03:35:47 0000-00-00 00:00:00 2020 0 ZDA 0 Nasl. z nasl. zaslona; Opis vira z dne 6. 12. 2019; str. e598-e601 iss. 3 Vol. 25 Mar. 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 1549-490X 10.1634/theoncologist.2019-0523 2048592241 521539609 RAZ_Cufer_Tanja_i2020.pdf RAZ_Cufer_Tanja_i2020.pdf 1 B9055D61D512AA3EFA4A3D6D02005C75 cef607e581aca7cc23c11321dad8454f9eb52a061303da2b5245dbbe5d64d538 8f606506-17b6-11ed-b6b8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=17335 https://theoncologist.onlinelibrary.wiley.com/doi/epdf/10.1634/theoncologist.2019-0523 1 https://dirros.openscience.si/Dokument.php?lang=slv&id=14610 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0