20.500.12556/DiRROS-12161 Clinical significance of histologic subtyping of malignant pleural mesothelioma Malignant mesothelioma (MM) is uncommon, but very aggressive tumor arising from the mesothelial cells of pleura, pericardium, peritoneum, and tunica vaginalis. Despite multimodality treatments 5-year survival is only 5% after the diagnosis. Histology and TNM staging system are still the best prognostic factors. Furthermore, histologic subtype of MM determines the clinical management of the patients. According to the 2015 WHO classification, MM is divided into diffuse, localized and well differentiated papillary mesothelioma. Major histologic subtypes of diffuse MM, namely epithelioid, biphasic and sarcomatoid, have different prognosis. However, in the last decade it has become evident that more detailed subclassification and histologic/cytological characterization of MM have prognostic and perhaps predictive implications. In this review, major histologic subtypes and cytological features of MM are presented and their relation with prognosis and predictive biomarkers is discussed. malignant mesothelioma epithelioid malignant mesothelioma biphasic malignant mesothelioma sarcomatoid malignant mesothelioma maligni mezoteliom epiteloidni maligni mezoteliom bifazni maligni mezoteliom sarkomatoidni maligni mezoteliom true false true AME Publishing Company Angleški jezik Ni določen http://tlcr.amegroups.com/article/view/38662 Translational lung cancer research Neznano 2020-06-22 12:48:20 2020-06-22 12:55:59 2022-08-18 03:35:34 0000-00-00 00:00:00 2020 0 Hong Kong 0 Nasl. z nasl. zaslona; Opis vira z dne 27. 5. 2020; str.1-10 iss. Vol. 9 2020 0000-00-00 PostprintKoncna VTisku NiDoloceno 0000-00-00 0000-00-00 0000-00-00 0000-00-00 616-006 2226-4477 10.21037/tlcr.2020.03.38 17124867 17120003 RAZ_Brcic_Luka_i2020.pdf RAZ_Brcic_Luka_i2020.pdf 1 7FB5E9D004DA51FE3C51F4D3271B9B52 162ec27bbfa8fdd84f24bf28ec31170575e2fa855de61f70b294846d1e59a7fd 8fbfb9e6-17b6-11ed-b6b8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=17340 http://tlcr.amegroups.com/article/view/38662/pdf 1 https://dirros.openscience.si/Dokument.php?lang=slv&id=14535 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0