Post-polymerization modification of poly(L-glutamic acid) with d-(+)-glucosaminePerdih, Peter (Avtor) Čebašek, Sašo (Avtor) Možir, Alenka (Avtor) Žagar, Ema (Avtor) poly(L-glutamic acid)glucosamineglycopolypeptideCarboxyl functional groups of poly(L-glutamic acid) (PGlu) were modified with a D-(+)-glucosamine (GlcN) by amidation using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4- methylmorpholinium chloride (DMTMM) as a coupling reagent. The coupling reaction was performed in aqueous medium without protection of hydroxyl functional groups of D-(+)-glucosamine. Poly(L-glutamic acid) and GlcN functionalized polyglutamates (P(Glu-GlcN)) were thoroughly characterized by 1D and 2D NMR spectroscopy and SEC-MALS to gain detailed information on their structure, composition and molar mass characteristics. The results reveal successful functionalization with GlcN through the amide bond and also to a minor extent through ester bond formation in position 1 of GlcN. In addition, a ratio between the α- and β-form of glucosamine substituent coupled to polyglutamate repeating units as well as the content of residual dimethoxy triazinyl active ester moiety in the samples were evaluated.20142014-12-16 15:08:53Članek v reviji755UDK: 620.1/.2ISSN pri članku: 1420-3049DOI: 10.3390/molecules191219751COBISS_ID: 5609754OceCobissID: 18462981sl