Patient-reported health-related quality of life impact and symptom severity in patients with Lyme borreliosis in the Burden of Lyme Disease (BOLD) studyYu, Holly (Avtor) Mercadante, Amanda R. (Avtor) Halsby, Kate (Avtor) Loew-Baselli, Alexandra (Avtor) Tan, Ye (Avtor) Edwards, Juanita (Avtor) Strle, Franc (Avtor) Lyme borreliosisLyme diseasedisseminated LBlocalized LBpatient-reported outcomesquality of lifeLyme borreliosis (LB) can manifest as a localized infection or, if left untreated, disseminated disease. This analysis used Patient-Reported Outcome tools to assess general health, fatigue, pain, and cognitive function in patients with localized or disseminated LB, compared with age- and site-matched controls without LB. All participants were enrolled in the Burden of Lyme Disease (BOLD) study; LB cases were assessed at 3 time points: the enrollment visit, and two follow-up visits conducted within 10 months of enrollment. Controls were evaluated at 2 time points: the enrollment contact and a follow-up contact 16–18 months post-enrollment. Symptom severity and general health quality between groups were compared using two-tailed Student’s t-tests and multivariate regression analyses. Disseminated LB cases reported greater fatigue and pain than localized LB (disseminated LB fatigue scores: 4.1, 3.7, and 3.5 at Visits 1, 2, and 3, respectively vs. localized LB: 2.9, 3.0, and 2.9; disseminated LB pain scores: 2.5, 1.6, and 1.3 vs. localized LB: 0.9, 0.6, and 0.8) and controls (fatigue score: 3.2; pain score: 1.0). Disseminated LB was also associated with reduced health-related quality of life. The results of this study indicate that health-related quality of life may vary by disease stage and that patients with disseminated disease showed persistent impairment during the acute phase and at 10-month follow-up.20262026-07-29 11:34:57Neznano31347UDK: 616.9ISSN pri članku: 2076-0817DOI: 10.3390/pathogens15070701COBISS_ID: 286281475sl