Pancreatic lymphoepithelial cyst with sebaceous differentiation-encountering and management of these rare tumoursBadovinac, David (Avtor) Luzar, Boštjan (Avtor) lymphoepithelial cystcystic lesions of the pancreassebaceous glandsBackground: Lymphoepithelial cysts (LECs) of the pancreas are rare, benign cystic lesions with unclear pathogenesis, and their diagnostic workup is often challenging. LECs with sebaceous differentiation are even more uncommon. They are typically solitary and asymptomatic, found in men and diagnosed incidentally. While imaging modalities and endoscopic ultrasound (EUS) may help identify cystic lesions of the pancreas, LECs can resemble other entities, making accurate preoperative diagnosis difficult. Final diagnosis is usually confirmed only after resection. Case summary: A 74-year-old male was incidentally diagnosed with an asymptomatic cystic lesion of the pancreas tail. While there were no deviations in laboratory workup or clinical examination, magnetic resonance imaging and EUS identified a cystic lesion 37 mm in diameter and filled with concentric nodules within fluid. Mucin was found within the cyst at biopsy, and mucinous cystic neoplasm was suspected. Laparoscopic distal pancreatectomy with splenectomy was performed, and pathological examination of the specimen identified an LEC with sebaceous glands. Conclusion: This article emphasizes the importance of recognizing the distinct characteristics of pancreatic LECs to help clinicians make more informed decisions and avoid unnecessary interventions. Continued reporting of similar cases is vital to improve our understanding and refine diagnostic strategies for these rare pancreatic lesions.20262026-07-29 08:42:21Neznano31339UDK: 616.3ISSN pri članku: 1948-9366DOI: 10.4240/wjgs.v18.i7.119186COBISS_ID: 286283523sl