Trends and determinants of C virus infection among people living with HIV in SloveniaLunar, Maja M. (Avtor) Seme, Katja (Avtor) Poljak, Mario (Avtor) HIVhepatitis CprevalenceSloveniantroduction: Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) share transmission routes and cause significant morbidity and mortality worldwide. Three previous nationwide studies reported a low prevalence of HCV infection among Slovenian people living with HIV (PLWH). Methods: Data were collected de novo from 526 PLWH newly diagnosed with HIV in Slovenia between January 1st, 2014, and December 31st, 2024, and combined with data from previous studies on this topic. Results: Altogether 1,085 (93%) PLWH were tested for HCV at HIV diagnosis: 82 (7.6%) had anti-HCV antibodies (49 or 59.8% of them viremic), and three had HCV RNA only, resulting in an HCV prevalence of 7.8%. A significant increase in the prevalence of HCV infection has been observed over the last decade. HCV infection was significantly associated with female sex, foreign nationality, parenteral HIV transmission route, and non-B HIV subtype. The most frequent HCV genotypes were 1 (60%), 3 (22%), and 4 (16%), markedly different than previously found in the general population. Conclusions: The overall prevalence of HCV infection among PLWH in Slovenia remains low, but a significant increase has been observed in the last decade compared to the previous one. Such a situation requires further regular and tight monitoring to allow timely interventions if and when needed.Združenje slovenskih dermatovenerologov20262026-07-02 11:10:03Neznano30773UDK: 616.9ISSN pri članku: 1318-4458DOI: 10.15570/actaapa.2026.2COBISS_ID: 277556739sl