Treatment of foreign body granulomas with combined enzyme therapyCastelanich, Desirée Giselle (Avtor) Pascuzzi, Delfina (Avtor) López Berroa, Jorge (Avtor) granulomacombined enzyme treatmentcollagenasehyaluronidaselipaseIntroduction: Granulomas are focal aggregates of inflammatory cells that form in response to a persistent inflammatory stimulus. Available therapies include surgical and nonsurgical management, and current evidence is based on case series or case reports. Methods: Two case reports of foreign body granulomas treated with a combination of recombinant enzymes (hyaluronidase, collagenase, and lipase of bacterial origin) are presented. Results: Following three sessions of combined enzyme treatment with a scheduled protocol, both patients showed clinical improvement without any reported adverse events. Conclusions: Combined enzyme therapy is an effective, safe, minimally invasive, innovative approach for the treatment of foreign body granulomas.Združenje slovenskih dermatovenerologov20252026-06-09 08:37:46Neznano29893UDK: 616.5:579ISSN pri članku: 1318-4458DOI: 10.15570/actaapa.2025.17COBISS_ID: 259281155sl