Predicting early preterm delivery and late fetal growth restriction by TNFαSharabi-Nov, Adi (Avtor) Fabjan-Vodušek, Vesna (Avtor) Premru-Sršen, Tanja (Avtor) Kumer, Kristina (Avtor) Fabjan, Teja (Avtor) Tul, Nataša (Avtor) Osredkar, Joško (Avtor) Nicolaides, Kypros H. (Avtor) Huppertz, Berthold (Avtor) Meiri, Hamutal (Avtor) fetal growth restrictiongestational weekinflammationmean arterial blood pressureplacental hypoxiaplacental perfusionpreeclampsiapregnancyWe evaluated tumor necrosis factor alpha (TNFα) and uterine artery pulsatility index (UtA-PI) in the triage of patients with suspected preterm delivery (PTD), preeclampsia (PE), fetal growth restriction (FGR), and PE+FGR. The study included 125 pregnant women attending high-risk pregnancy clinics for triage of pregnancy complications. There were 31 pure PE cases, 42 cases of PE combined with FGR, 16 pure FGR cases, 15 PTD cases, and 21 term normal delivery controls. Maternal serum TNFα was determined by immune-diagnostic testing. UtA-PI was measured by Doppler sonography. Demographic, medical and pregnancy history, and mean arterial blood pressure (MAP) were extracted from the hospital medical records. Linear regression coefficients, and Box and Whisker plots were calculated and depicted using non-parametric statistics (Kruskal Wallis and Mann–Whitney). Spearman’s regression coefficient assessed marker accuracy; p<0.05 was considered significant. It was found that high TNFα in cases <34 weeks gestation, when coupled to low UtA-PI and normal blood pressure are found in early PTD most likely linked to maternal inflammation. At term, high TNFα combined with high UtA-PI is associated with any FGR (with/without PE), possibly reflecting inflammation and maternal and fetal hypoxia due to the very long period of altered placental perfusion. Accordingly, TNFα, and Doppler UtA-PI could be used for the differential diagnosis of early PTD, and FGR (with/without PE) near delivery.20252026-05-18 12:32:27Neznano29421UDK: 618.3-008.6ISSN pri članku: 2575-8594DOI: 10.19080/GJORM.2025.11.555807COBISS_ID: 226434563sl