Suboptimal management of hypercholesterolemia in countries with high or very high cardiovascular riskŠabovič, Mišo (Avtor) Pejkov, Hristo (Avtor) Caraus, Alexandru (Avtor) Gruev, Ivan (Avtor) Vintilă, Vlad Damian (Avtor) Csanádi, Zoltán (Avtor) Batjargal, Sodgerel (Avtor) Kovačević -Preradović, Tamara (Avtor) Kusljugić, Zumreta (Avtor) Kuprešak, Draško (Avtor) LDL-Chypercholesterolemialipid-lowering therapyESC/EAS guidelinescardiovascular riskreal-world evidencestatinsezetimibeIntroduction: The 2019 ESC/EAS guidelines introduced stricter low-density lipoprotein cholesterol (LDL-C) targets, particularly for patients at high and very high cardiovascular (CV) risk. However, data on the implementation of these targets in real-world clinical practice—especially in countries with high/very high CV risk—remain limited. The DISCOVERY study aimed to assess LDL-C management, lipid-lowering therapy (LLT) use, and guideline adherence across multiple countries in Central and Eastern Europe and Central Asia. Methods: This prospective, observational, multicenter study enrolled adult patients with hypercholesterolemia (HCL) from 10 countries grouped into three regions. Data was collected at baseline and after 12 weeks of follow-up. LLT patterns, LDL-C levels, target attainment (both investigator-defined and 2019 ESC/EAS-recommended), and physician adherence to guidelines were analyzed. Results: A total of 6,447 patients were included; 53.2% were female, and the mean age was 60.5 ± 11.9 years. Most patients (66%) were in secondary prevention. At baseline, 36.8% had been treated with LLT. After the first visit, treatment was changed in 78% of patients, but only 42.4% received highintensity statins and 9.3% received statin-ezetimibe combinations at followup. LDL-C target achievement was poor: only 5.6% of patients met the guideline-recommended LDL-C goals, compared to 45.5% who met physician-defined targets. Among patients with ASCVD, only 3.3% achieved guideline LDL-C targets. The most significant gap was observed between guideline recommendations and physician-set LDL-C goals. No significant difference in LDL-C target attainment was observed between specialists and general practitioners. Discussion: The DISCOVERY study reveals suboptimal LDL-C control and low adherence to the 2019 ESC/EAS guidelines in routine practice across countries with high/very high CV risk. These findings highlight the urgent need for strategies to improve physician awareness, promote intensive LLT use, and close the gap between guidelines and clinical practice. A paradigm shift toward proactive LDL-C management is essential to reduce residual CV risk in these populations.20252026-03-31 12:50:39Neznano28735UDK: 616.1ISSN pri članku: 2297-055XDOI: 10.3389/fcvm.2025.1665059COBISS_ID: 270944259sl