Polymorphisms rs1800587 and rs1143634 of the interleukin-1α gene are associated with the progression of carotid atherosclerosis in Caucasians with type 2 diabetes mellitusPleskovič, Aleš (Avtor) Nikolajević, Jovana (Avtor) Mankoč Ramuš, Sara (Avtor) Cilenšek, Ines (Avtor) Šantl-Letonja, Marija (Avtor) Makuc, Jana (Avtor) Cokan Vujkovac, Andreja (Avtor) Petrovič, Danijel (Avtor) carotid atherosclerosisgenetic polymorphisminterleukin-1 αcross-sectional studyBackground: Our study was designed to test the possible association between either polymorphisms T889C (rs1800587) or C3954T (rs1143634) of the interleukin-1 alpha (IL-1α) gene with subclinical markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM). Moreover, the effect of both polymorphisms on progression of carotid atherosclerosis in 3.8-year follow-up was studied. Patients and methods: 595 subjects with T2DM were enrolled in the prospective study. Subclinical markers of carotid atherosclerosis were assessed with ultrasound at the time of recruitment and after 3.8-years. Genotyping of two polymorphisms (rs1800587, rs1143634) was performed with real-time PCR System. Results: The comparison of atherosclerosis parameters was performed with regard to different genotypes of IL-1α rs1800587 and rs1143634 polymorphisms upon enrolment. Multiple linear regression analysis revealed the association of IL-1α rs1143634 on total plaque thickness progression in a 3.8 year follow up. Conclusions: An association between either the IL-1α rs1800587 or rs1143634 and total plaque thickness at the time of recruitment was reported. Additionally, we demonstrated the effect of the IL-1α rs1143634 on total plaque thickness progression in the 3.8-year follow-up in patients with T2DM.20162026-01-12 15:08:34Neznano25147UDK: 61ISSN pri članku: 2475-3211DOI: 10.4172/2475-3211.1000113COBISS_ID: 263106563slV članku navedeno: "This is an open-access article distributed under the terms of the Creative Commons Attribution License." Na spletni strani revije navedeno: "Creative Commons License CC BY-NC-ND 4.0" (https://www.hilarispublisher.com/policies.html. 12. 1. 2026).