Association of tumor-infiltrating lymphocytes and inflammation status with survival outcome in patients with high-grade serous ovarian carcinomaMiceska, Simona (Avtor) Grašič-Kuhar, Cvetka (Avtor) Frković-Grazio, Snježana (Avtor) Škof, Erik (Avtor) Krishnamoorthy, Praveen (Avtor) Khabele, Dineo (Avtor) Kloboves-Prevodnik, Veronika (Avtor) ovarian carcinomahigh-grade serous ovarian carcinomaprognostic factorsIn this study, we investigated the association between tumor-infiltrating lymphocytes (TILs), inflammation status, and progression-free survival (PFS) in patients with primary high-grade serous ovarian carcinoma (HGSC). We assessed the percentages of different intraepithelial and stromal TIL subtypes using both manual and digital methods, following established recommendations for TIL assessment. In addition, we evaluated inflammation status through several immune scores, including the pan-immune-inflammation value (PIV). Our results suggest that stromal CD3+ and CD8+ TILs, as well as PIV, may serve as potential prognostic indicators in HGSC, as they remained potential independent markers in multivariate analysis.MDPI, Basel, Switzerland20252025-11-27 03:58:43Neznano24412UDK: 618.1ISSN pri članku: 2072-6694DOI: 10.3390/cancers17142269COBISS_ID: 241873923Basel, Switzerlandslby Authors