Cold-induced anaphylaxisBizjak, Mojca (Avtor) Korošec, Peter (Avtor) Košnik, Mitja (Avtor) Šelb, Julij (Avtor) Bidovec, Urška (Avtor) Svetina, Manca (Avtor) Zver, Samo (Avtor) Dinevski, Dejan (Avtor) Rijavec, Matija (Avtor) anaphylaxiscold urticariahereditary α-tryptasemiaKIT p.D816Vmast celltotal IgEtryptaseThe pathogenesis of cold urticaria (ColdU) and cold-induced anaphylaxis (ColdA) remains poorly understood, and ColdA is underrepresented in anaphylaxis literature. Laboratory features to guide management are largely unknown. This study evaluated basal serum tryptase (BST) and total immunoglobulin E (IgE) levels in ColdU and ColdA, their associations with clinical features, and the utility of testing for the KIT p.D816V variant in blood leukocytes and hereditary a-tryptasemia (HaT).Frontiers Research Foundation, 2010-20252025-05-21 11:00:44Neznano22491UDK: 616-097ISSN pri članku: 1664-3224DOI: 10.3389/fimmu.2025.1558284COBISS_ID: 229318403Frontiers in immunologysl© 2025 Bizjak, Korošec, Košnik, Šelb, Bidovec-Stojkovič, Svetina, Zver, Dinevski and Rijavec. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.