Defining remission in childhood-onset lupusSmith, Eve Mary Dorothy (Avtor) Aggarwal, Amita (Avtor) Ainsworth, Jenny (Avtor) Al-Abadi, Eslam (Avtor) Avčin, Tadej (Avtor) Bortey, Lynette (Avtor) Burnham, Jon (Avtor) Ciurtin, Coziana (Avtor) Hedrich, Christian M. (Avtor) Kamphuis, Sylvia (Avtor) autoinflammatory diseaseslupustreat-to-targetremissionchildrenObjective: To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice. Method:s The cSLE International T2T Task Force conducted Delphi surveys exploring paediatric perspectives on adult-onset SLE remission targets. A modified nominal group technique was used to discuss, refine, and agree on the cSLE remission target criteria. Results: The Task Force proposed two definitions of remission: ‘cSLE clinical remission on steroids (cCR)’ and ‘cSLE clinical remission off steroids (cCR-0)’. The common criteria are: (1) Clinical-SLEDAI-2 K = 0; (2) PGA score < 0.5 (0–3 scale); (4) stable antimalarials, immunosuppressive, and biologic therapy (changes due to side-effects, adherence, weight, or when building up to target dose allowed). Criterion (3) in cCR is the prednisolone dose ≤0.1 mg/kg/day (maximum 5 mg/day), whereas in cCR-0 it is zero. Conclusions: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research.20242026-06-05 09:24:56Neznano29776sl