The significance of isolated de novo red patches in the bladder in patients referred with suspected urinary tract cancerKhadhouri, Sinan (Avtor) Gallagher, Kevin M (Avtor) MacKenzie, Kenneth R. (Avtor) Shah, Taimur T. (Avtor) Gao, Chuanyu (Avtor) Kondža, Andraž (Sodelavec pri raziskavi) Hawlina, Simon (Sodelavec pri raziskavi) Smrkolj, Tomaž (Sodelavec pri raziskavi) Bele, Uroš (Sodelavec pri raziskavi) biopsybladder cancercystoscopyhaematuriared patchrisk factorsObjectives: To assess the contemporary malignancy rate in isolated de novo red patchesin the bladder and associated risk factors for better selection of red patch biopsy.Patients: Patients from the IDENTIFY dataset; Patients referred to secondary carewith suspected urinary tract cancer and found to have isolated de novo red patcheson cystoscopy.Methods: We reported the unadjusted cancer prevalence in isolated de novo redpatches that were biopsied; multivariable logistic regression was used to explorecancer-associated risk factors including age, sex, smoking, type of haematuria, LUTS,UTIs and a suspicious-looking red patch (as reported by the cystoscopist). Sub-analysis of these by clinical role and experience was performed.Results: A total of 1110 patients with isolated de novo red patches were included.41.5% (n = 461) were biopsied, with a malignancy rate of 12.8% (59/461), whichwas significantly higher in suspicious versus non-suspicious red patches (19.1%vs. 2.81%, p < 0.01). There was a significant association between bladder cancer andage (OR 1.04, 95% CI 1.01–1.07, p = 0.01), smoking history (OR 2.62, 95% CI 1.09–6.27, p = 0.03) and suspicious-looking patch (OR 6.50, 95% CI 2.47–17.1, p < 0.01).The majority of malignancies were in over 60-year-olds. Malignancy rates in suspicious versus non-suspicious red patches did not differ significantly betweenclinical roles or experiences.Limitations included subjectivity in classifying a suspicious patch and selection biasas not all patches were biopsied.Conclusions: Many patients still undergo unnecessary biopsies under general anaes-thetic for isolated de novo red patches. Clinicians should consider the patient’s age,smoking status and how suspicious-looking the patch is, before deciding on surveil-lance versus biopsy to improve cancer diagnostic yield.20252026-04-09 14:25:00Neznano28862sl