Clinical outcome of hypertrophic cardiomyopathy in probands with the founder variant c.913_914del in MYBPC3Vodnjov, Nina (Avtor) Maver, Aleš (Avtor) Teran, Nataša (Avtor) Peterlin, Borut (Avtor) Toplišek, Janez (Avtor) Writzl, Karin (Avtor) cardiogeneticscardiologyMYBPC3hypertrophic cardiomyopathyHypertrophic cardiomyopathy is often caused by pathogenic MYBPC3 variants. The study of Italian patients with HCM and MYBPC3(NM_000256.3):c.913_914del showed a higher disease penetrance in males and a higher frequency of arrhythmias compared to patients with other likely pathogenic and pathogenic (LP/P) MYBPC3 variants. We investigated the clinical outcomes of Slovenian probands with MYBPC3 LP/P variants, estimated the variant penetrance and compared the results with an Italian study. We identified 31 haplotype-matched individuals with MYBPC3:c.913_914del and 34 individuals with other LP/P MYBPC3 variants. We observed some significant differences in clinical and echocardiographic characteristics and frequency of adverse cardiac events between Slovenian and Italian probands with MYBPC3:c913_914del. We were unable to replicate previous findings for MYBPC3:c.913_914del, highlighting the complexity of genotype–phenotype associations.20252026-03-16 10:59:18Neznano28375sl