Prognostic impact of interleukin-27 in peripheral artery diseaseKokalj, Nataša (Avtor) Jug, Borut (Avtor) peripheral artery diseaseinterleukin-27endovascular revascularizationmajor adverse cardiovascular eventsmajor adverse limb eventsAtherosclerosis is a progressive arterial disease characterized by chronic inflammation, with interleukin-27 (IL-27) implicated as both a pro- and anti-inflammatory cytokine. This prospective cohort study evaluated association of circulating IL-27 levels in peripheral artery disease patients undergoing elective endovascular revascularization, with major adverse cardiovascular events (MACE) and major adverse limb events (MALE) over a median follow-up of 311 days. Elevated IL-27 levels were significantly associated with increased risk of MACE and MALE in unadjusted analyses. After adjusting for established cardiovascular and PAD risk factors, IL-27 remained an independent predictor of MACE (HR 2.95; p = 0.039), but not MALE. These findings indicate that elevated IL-27 levels are associated with unfavourable long-term prognosis.20252026-03-06 15:20:16Neznano28035sl