Longitudinal study of malignancy associated changes in progressive cervical dysplasiaStrojan Fležar, Margareta (Avtor) Lavrenčak, Jaka (Avtor) Žganec, Mario (Avtor) Us-Krašovec, Marija (Avtor) Eight of 29 patients with progressive CIN were followed for 2 to 10 years. Their consecutive Pap smears were destained and stained according to Feulgen thionin method. Cyto-Savant/TM high resolution image cytometer (Oncometrics Technol. Corp., Vancouver, Canaderage values of muclear texture features and their probability distributions for consecutive Pap smears from each patient were calculated. Three out of 5 discriminant MAC, highDNAamount, highDNAcomp and highDNAarea, were to increase as a function of time in 5 out of 8 patients. A preliminary analysis which was performed on non-standardized archival material demonstrated a monotonous increase of discrete texture features as a function of time in patients with progressive CIN.Slovenian Medical Society - Section of Radiology ; Croatian Medical Association - Croatian Society of Radiology19982024-01-19 12:27:23Neznano17890Ljubljanaslby Authors