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2. Bioresorbability dependence on microstructure of additivelly- manufactured and conventionally-produced Fe-Mn alloysMatjaž Godec, Jakob Kraner, Danijela Anica Skobir Balantič, Irena Paulin, Damjana Drobne, Veno Kononenko, Aleksandra Kocijan, Paul J. McGuiness, Črtomir Donik, 2024 Opis: The dataset supports the results shown in the tables and figures in the article entitled “Bioresorbability Dependence on Microstructure of Additivelly-Manufactured and Conventionally-Produced Fe-Mn Alloys” (doi.org/10.1016/j.jmrt.2024.04.097). It contains measurements of corrosion resistance of Fe-Mn samples, phase analysis of samples A, B and C, surface and depth profiling XPS, EDS measurements of a cross-section of Fe-Mn powder particles and viability measurements results.
Ključne besede: Fe-Mn alloy, laser powder bed fusion, bioresorbable, microstructure, corrosion behaviour, biocompatibility
Objavljeno: 12.04.2024; Ogledov: 142; Prenosov: 53
 Celotno besedilo (2,55 MB)
Ogledov v tednu: 84 |
3. State of the art methodologies for the estimation of fire costs in buildings to support cost–benefit analysisIkwulono David Unobe, Andrea Lucherini, Shuna Ni, Thomas Gernay, Ranjit Kumar Chaudhary, Ruben Van Coile, 2024 Opis: Fires can lead to costly building damage as well as loss of lives and injuries. Installed to protect buildings from fire, or to limit the damage from such outbreaks, fire protection measures are a common feature in buildings. However, these features come at a cost. Although quite ubiquitous in buildings, the value of these features to private individuals and to society is not fully understood. To understand their value, a cost benefit analysis detailing the costs and benefits of fire protection measures is needed. Carrying out such an analysis requires methods for computing both the cost of these fire protection measures, and losses from fires (including both direct and indirect losses). This study outlines methodologies for evaluating those costs and losses. An exhaustive collection of available data necessary for estimating both costs and losses is presented. Several limitations in current methodologies and data constraints were identified, with recommendations proposed to address these shortcomings. Relevant sections of a study by the authors that refines fire protection cost estimation at national and sub-national levels are emphasized, including updated building categories, guidance on computing multipliers, and detailed cost calculation methods for installation and maintenance costs. The calculation uses regularly updated U.S. Census Bureau construction data, ensuring timely multiplier updates. The insights and suggestions presented in this study will ultimately refine the process of selecting fire protection strategies that maximize the net benefit of fire protection measures for both private stakeholders and society at large.
Ključne besede: fire protection measures, cost of fire protection, losses from fire, cost benefit analysis, installation costs, maintenance costs
Objavljeno: 18.04.2024; Ogledov: 83; Prenosov: 12
 Celotno besedilo (879,08 KB)
Ogledov v tednu: 83 |
4. Recombinant human erythropoietin alters gene expression and stimulates proliferation of MCF-7 breast cancer cellsNina Trošt, Tina Stepišnik, Sabina Berne, Anja Pucer Janež, Toni Petan, Radovan Komel, Nataša Debeljak, 2013 Opis: Background. Functional erythropoietin (EPO) signaling is not specific only to erythroid lineages and has been confirmed in several solid tumors, including breast. Three different isoforms of erythropoietin receptor (EPOR) have been reported, the soluble (EPOR-S) and truncated (EPOR-T) forms acting antagonistically to the functional EPOR. In this study, we investigated the effect of human recombinant erythropoietin (rHuEPO) on cell proliferation, early gene response and the expression of EPOR isoforms in the MCF-7 breast cancer cell line.Materials and methods. The MCF-7 cells were cultured with or without rHuEPO for 72 h or 10 weeks and assessed for their growth characteristics, expression of early response genes and different EPOR isoforms. The expression profile of EPOR and EPOR-T was determined in a range of breast cancer cell lines and compared with their invasive properties.Results. MCF-7 cell proliferation after rHuEPO treatment was dependent on the time of treatment and the concentration used. High rHuEPO concentrations (40 U/ml) stimulated cell proliferation independently of a preceding long-term exposure of MCF-7 cells to rHuEPO, while lower concentrations increased MCF-7 proliferation only after 10 weeks of treatment. Gene expression analysis showed activation of EGR1 and FOS, confirming the functionality of EPOR. rHuEPO treatment also slightly increased the expression of the functional EPOR isoform, which, however, persisted throughout the 10 weeks of treatment. The expression levels of EPOR-T were not influenced. There were no correlations between EPOR expression and the invasiveness of MCF-7, MDA-MB-231, Hs578T, Hs578Bst, SKBR3, T-47D and MCF-10A cell lines.Conclusions. rHuEPO modulates MCF-7 cell proliferation in time- and concentration-dependent manner. We confirmed EGR1, FOS and EPOR as transcription targets of the EPO-EPOR signaling loop, but could not correlate the expression of different EPOR isoforms with the invasiveness of breast cancer cell lines.
Ključne besede: breast cancer, erythropoietin, gene expression
Objavljeno: 22.03.2024; Ogledov: 180; Prenosov: 44
Celotno besedilo (850,15 KB)
Ogledov v tednu: 81 |
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6. Fungal community composition predicts forest carbon storage at a continental scaleMark A. Anthony, Leho Tedersoo, Bruno De Vos, Luc Croisé, Henning Meesenburg, Markus Wagner, Henning Andreae, Frank Jacob, Paweł Lech, Anna Kowalska, Aleksander Marinšek, 2024 Opis: Forest soils harbor hyper-diverse microbial communities which fundamentally regulate carbon and nutrient cycling across the globe. Directly testing hypotheses on how microbiome diversity is linked to forest carbon storage has been difficult, due to a lack of paired data on microbiome diversity and in situ observations of forest carbon accumulation and storage. Here, we investigated the relationship between soil microbiomes and forest carbon across 238 forest inventory plots spanning 15 European countries. We show that the composition and diversity of fungal, but not bacterial, species is tightly coupled to both forest biotic conditions and a seven-fold variation in tree growth rates and biomass carbon stocks when controlling for the effects of dominant tree type, climate, and other environmental factors. This linkage is particularly strong for symbiotic endophytic and ectomycorrhizal fungi known to directly facilitate tree growth. Since tree growth rates in this system are closely and positively correlated with belowground soil carbon stocks, we conclude that fungal composition is a strong predictor of overall forest carbon storage across the European continent.
Ključne besede: fungal community, carbon storage, forest
Objavljeno: 19.04.2024; Ogledov: 69; Prenosov: 26
Celotno besedilo (2,55 MB)
Ogledov v tednu: 69 |
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8. Urban greenspaces and nearby natural areas support similar levels of soil ecosystem servicesDavid J. Eldridge, Haiying Cui, Jingyi Ding, Miguel Berdugo, Tadeo Sáez-Sandino, Jorge Duran, Juan J. Gaitan, José L. Blanco-Pastor, Alexandra Rodríguez, César Plaza, Tine Grebenc, Tina Unuk Nahberger, 2024 Opis: Greenspaces are important for sustaining healthy urban environments and their human populations. Yet their capacity to support multiple ecosystem services simultaneously (multiservices) compared with nearby natural ecosystems remains virtually unknown. We conducted a global field survey in 56 urban areas to investigate the influence of urban greenspaces on 23 soil and plant attributes and compared them with nearby natural environments. We show that, in general, urban greenspaces and nearby natural areas support similar levels of soil multiservices, with only six of 23 attributes (available phosphorus, water holding capacity, water respiration, plant cover, arbuscular mycorrhizal fungi (AMF), and arachnid richness) significantly greater in greenspaces, and one (available ammonium) greater in natural areas. Further analyses showed that, although natural areas and urban greenspaces delivered a similar number of services at low (>25% threshold) and moderate (>50%) levels of functioning, natural systems supported significantly more functions at high (>75%) levels of functioning. Management practices (mowing) played an important role in explaining urban ecosystem services, but there were no effects of fertilisation or irrigation. Some services declined with increasing site size, for both greenspaces and natural areas. Our work highlights the fact that urban greenspaces are more similar to natural environments than previously reported and underscores the importance of managing urban greenspaces not only for their social and recreational values, but for supporting multiple ecosystem services on which soils and human well-being depends.
Ključne besede: soil, ecosystem services, urban forests
Objavljeno: 17.04.2024; Ogledov: 79; Prenosov: 33
Celotno besedilo (1,91 MB)
Ogledov v tednu: 68 |
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