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Title:Sistemsko zdravljenje napredovalega medularnega karcinoma ščitnice
Authors:Grašič-Kuhar, Cvetka (Author)
Language:Slovenian
Tipology:1.02 - Review Article
Organisation:LogoOI - Institute of Oncology
Abstract:Medularni karcinom ščitnice nastane iz nevroendokrinih celic ščitnice, ki izločajo kalcitonin. Kalcitonin je specifičen marker medularnega raka ščitnice. Pri lokalno napredovalem ali metastaskem medularnem raku ščitnice ob simptomtskem progresu prihaja v poštev zdravljenje s tirozin kinaznimi inhibitorji. Registrirani substanci sta vandetanib in cabozantinib, učinkoviti pa sta tudi sorafenib in sunitinib. Izbira zdravljenja je individualizirana glede na breme bolezni in spremljajoče bolezni. Zelo pomembno je tudi podporno (na simptome usmerjeno) zdravljenje.
Keywords:medularni karcinom ščitnice, rak ščitnice, sistemsko zdravljenje, napredovali rak
Year of publishing:2016
COBISS_ID:2415739 Link is opened in a new window
UDC:616.4
ISSN on article:1408-1741
OceCobissID:65324032 Link is opened in a new window
Views:1179
Downloads:55
Files:.pdf PDF - Presentation file, download (430,68 KB)
 
Metadata:XML RDF-CHPDL DC-XML DC-RDF
Licenca:Creative Commons Priznanje avtorstva 4.0 Novo okno
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Secondary language

Language:English
Title:Systemic Treatment of Advanced Medullary Thyroid Carcinoma
Abstract:Medullary thyroid carcinoma originates from neuroendocrine cells of the thyroid which secrete calcitonin. Calcitonin is a specific marker for medullary thyroid cancer. Therapy with tyrosine kinase inhibitors can be applied to treat locally advanced or metastatic medullary thyroid cancer with progressing symptoms. Registered substances used are vandetanib and cabozantinib, and sorafenib and sunitinib are also effective. Treatment is determined individually based on the burden of the cancer and secondary diseases. Supportive treatment (targeted at the symptoms) is also very important.
Keywords:systemic treatment, medullary thyroid carcinoma, thyroid cancer

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