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Naslov:Immunological outcomes of allergen-specific immunotherapy in food allergy
Avtorji:Schoos, Anne-Marie Malby (Avtor)
Bullens, Dominique (Avtor)
Chawes, Bo Lund (Avtor)
Costa, Joana (Avtor)
De Vlieger, Liselot (Avtor)
DunnGalvin, Audrey (Avtor)
Epstein, Michelle M. (Avtor)
Garssen, Johan (Avtor)
Hilger, Christiane (Avtor)
Knipping, Karen (Avtor)
Zidarn, Mihaela (Avtor)
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik
Povzetek:IgE-mediated food allergies are caused by adverse immunologic responses to food proteins. Allergic reactions may present locally in different tissues such as skin, gastrointestinal and respiratory tract and may result is systemic life-threatening reactions. During the last decades, the prevalence of food allergies has significantly increased throughout the world, and considerable efforts have been made to develop curative therapies. Food allergen immunotherapy is a promising therapeutic approach for food allergies that is based on the administration of increasing doses of culprit food extracts, or purified, and sometime modified food allergens. Different routes of administration for food allergen immunotherapy including oral, sublingual, epicutaneous and subcutaneous regimens are being evaluated. Although a wealth of data from clinical food allergen immunotherapy trials has been obtained, a lack of consistency in assessed clinical and immunological outcome measures presents a major hurdle for evaluating these new treatments. Coordinated efforts are needed to establish standardized outcome measures to be applied in food allergy immunotherapy studies, allowing for better harmonization of data and setting the standards for the future research. Several immunological parameters have been measured in food allergen immunotherapy, including allergen-specific immunoglobulin levels, basophil activation, cytokines, and other soluble biomarkers, T cell and B cell responses and skin prick tests. In this review we discuss different immunological parameters and assess their applicability as potential outcome measures for food allergen immunotherapy that may be included in such a standardized set of outcome measures.
Ključne besede:food hypersensitivity, food intolerance, immunotherapy, immunology, food allergy, food allergens, oral immunotherapy
Leto izida:2020
Založnik:Frontiers Research Foundation
Izvor:Švica
UDK:616-097
ISSN pri članku:1664-3224
OceCobissID:30774233 Povezava se odpre v novem oknu
COBISS_ID:50624515 Povezava se odpre v novem oknu
DOI:10.3389/fimmu.2020.568598 Povezava se odpre v novem oknu
Opombe:Nasl. z nasl. zaslona; Soavtorica iz Slovenije: Mihaela Zidarn; Opis vira z dne 9. 2. 2021;
Število ogledov:30
Število prenosov:9
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://www.frontiersin.org/articles/10.3389/fimmu.2020.568598/full#supplementary-material
 
Nadgradivo:Front. immunol.
Frontiers Research Foundation
 
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Avtorske pravice:© 2020 Schoos, Bullens, Chawes, Costa, De Vlieger, DunnGalvin, Epstein, Garssen, Hilger, Knipping, Kuehn, Mijakoski, Munblit, Nekliudov, Ozdemir, Patient, Peroni, Stoleski, Stylianou, Tukalj, Verhoeckx, Zidarn and van de Veen.
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Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:03.11.2020

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