Digitalni repozitorij raziskovalnih organizacij Slovenije

Izpis gradiva
A+ | A- | SLO | ENG

Naslov:Chemokines during anaphylaxis : the importance of CCL2 and CCL2-dependent chemotactic activity for basophils
Avtorji:Vantur, Romana (Avtor)
Rihar, Maruša (Avtor)
Koren, Ana (Avtor)
Rijavec, Matija (Avtor)
Kopač, Peter (Avtor)
Bidovec, Urška (Avtor)
Eržen, Renato (Avtor)
Korošec, Peter (Avtor)
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik
Povzetek:Background: The role of chemokines in anaphylaxis is unclear. Methods: We prospectively recruited 49 patients presenting to the emergency department with an acute episode of anaphylaxis and 28 healthy subjects. We measured serum levels of the chemokines CCL2, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL21, CCL22, CCL24, and CCL26, tryptase, the absolute number of circulating basophils, monocytes, lymphocytes, and PMNs, and whole blood FCER1A, CPA3 and HDC gene expression at two time points: during the anaphylactic episode and in convalescent samples collected approximately 3 months later. We then investigated the in vitro chemotactic activity of chemokines induced during anaphylaxis for the in vitro migration of the corresponding cells. Results: Only CCL2 chemokine levels were signifcantly increased in anaphylaxis samples (median 514 pg/ml) compared to convalescent samples (284 pg/ml, P<0.0001) and healthy subjects (279 pg/ml, P<0.0001); there was no signifcant diference in any of the other chemokines. There was a signifcant positive correlation between the rates of increase of serum CCL2 (median [range]: 106.0% [-44.7% to 557.4%]) and tryptase (133.8% [-6.6% to 893.4%]; r=0.68, P<0.0001) and between the acute concentration of serum CCL2 and the acute concentration of serum tryptase (r=0.77, P<0.0001). The number of circulating basophils, but not other blood cells, signifcantly decreased during anaphylaxis (median 5.0 vs. 19.1 cells/[micro]l in convalescent samples; P<0.0001); a decrease in whole-blood gene expression of basophil markers (P
Ključne besede:anaphylaxis, chemokines, tryptases, basophils, chemotaxis, CCL2, cell migration
Leto izida:2020
Založnik:Springer Nature
Izvor:Velika Britanija
UDK:616-097
ISSN pri članku:2045-7022
OceCobissID:31507929 Povezava se odpre v novem oknu
COBISS_ID:43048963 Povezava se odpre v novem oknu
DOI:10.1186/s13601-020-00367-2 Povezava se odpre v novem oknu
Opombe:Nasl. z nasl. zaslona; Soavtorji: Maruša Rihar, Ana Koren, Matija Rijavec, Peter Kopač, Urška Bidovec-Stojković, Renato Eržen, Peter Korošec; Opis vira z dne 16. 12. 2020; Št. članka: 63;
Število ogledov:101
Število prenosov:63
Datoteke:.pdf PDF - Predstavitvena datoteka, prenos (2,04 MB)
 
Nadgradivo:Clinical and translational allergy
BioMed Central
 
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Avtorske pravice:© The Author(s) 2020
:
  
Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše podrobnosti ali sproži prenos.


Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:15.12.2020

Nazaj