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Title:Elektrokemoterapija : učinki na žilje tumorja
Authors:ID Serša, Gregor (Author)
ID Čemažar, Maja (Author)
ID Snoj, Marko (Author)
Files:.pdf PDF - Presentation file, download (234,19 KB)
MD5: 7126805EDD52124EB34E9C996B98E453
 
URL URL - Source URL, visit http://www.dlib.si/details/URN:NBN:SI:doc-QNFAG9YH
 
Language:Slovenian
Typology:1.04 - Professional Article
Organization:Logo OI - Institute of Oncology
Abstract:Terapevtska učinkovitost zdravljenj, ki delujejo na žilje tumorja, je sedaj splošno priznana. Odkrivajo se vedno nova zdravila in pristopi, ki ciljajo žilje tumorja, zato jih imenujemo žilno ciljano zdravljenje (vascular targeted therapies). Poznamo dve vrsti tega zdravljenja, in sicer antiangiogeno (anti-angiogenic therapies) in žilno razdiralno (vascular-disrupting therapies). Ločita se po fizioloških tarčah, primernosti za zdravljenje glede na obseg bolezni in režimu zdravljenja. Zadnja odkritja kažejo, da ima elektrokemoterapija poleg neposrednega citotoksičnega delovanja tudi žilno razdiralni učinek, ker na endotelne celice tumorskega žilja deluje citotoksično. Zaradi odmiranja teh celic prihaja do trajnih ustavitev pretoka krvi in do ishemičnega propada tumorskih celic v poškodovanih delih tumorja. Zaradi žilno razdiralnega učinka je elektrokemoterapija učinkovita tudi pri zdravljenju krvavečih tumorskih lezij, kar se kaže v takojšnji ustavitvi krvavitve in v poznejšem zmanjšanju tumorske lezije. Raziskave je podprla ARRS.
Publication status:Published
Publication version:Version of Record
Year of publishing:2008
Number of pages:str. 132-134
Numbering:Letn. 12, št. 2
PID:20.500.12556/DiRROS-13642 New window
UDC:616-006
ISSN on article:1408-1741
URN:URN:NBN:SI:doc-QNFAG9YH
COBISS.SI-ID:25340889 New window
Copyright:by Authors
Note:BSDOCID143393;
Publication date in DiRROS:05.01.2021
Views:1078
Downloads:454
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Record is a part of a journal

Title:Onkologija. strokovni časopis za zdravnike
Shortened title:Onkologija
Publisher:Onkološki inštitut
ISSN:1408-1741
COBISS.SI-ID:65324032 New window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:31.12.2008

Secondary language

Language:Undetermined
Title:Vascular Disrupting Effect of Electrochemotherapy
Abstract:The therapeutic potential of targeting the tumor blood supply is now well acknowledged. Vascular targeted therapies target tumor blood vessels. The research and development have resulted in a variety of investigational agents, among which many are currently being clinically tested. Two distinct groups of vascular targeted therapies have evolved, anti-angiogenic and vascular-disrupting approach. They differ in several aspects: their physiological target, the type and extent of the disease which is likely to be susceptible to one or the other group of therapies, and their treatment scheduling. Besides the direct cytotoxic effect of electrochemotherapy on tumor cells, recent discoveries have detected also its vascular-disrupting effect. Due to vascular damage, abrogation of tumor blood flow, and consequently, of tumor ischemia, a cascade of tumor-cell deaths is induced. Therefore, electrochemotherapy is effective in the treatment of bleeding metastases due to its vascular disrupting effect; it quickly stops bleeding and reduces tumor burden.


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