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Naslov:Cabbage and fermented vegetables : from death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19
Avtorji:ID Bousquet, Jean (Avtor)
ID Antò i Boquè, Josep M. (Avtor)
ID Czarlewski, Wienczyslawa (Avtor)
ID Haahtela, Tari (Avtor)
ID Fonseca, Susana C. (Avtor)
ID Laccarino, Guido (Avtor)
ID Blain, Hubert (Avtor)
ID Vidal, Alain (Avtor)
ID Sheikh, Aziz (Avtor)
ID Akdis, Cezmi A. (Avtor)
ID Zuberbier, Torsten (Avtor)
ID Kreft, Samo (Avtor)
ID Jenko, Klemen (Avtor)
ID Jošt, Maja, Klinika Golnik (Avtor)
ID Kopač, Peter, Klinika Golnik (Avtor)
ID Košnik, Mitja, Klinika Golnik, Medicinska fakulteta UL (Avtor)
ID Kramer Vrščaj, Karmen (Avtor)
ID Madjar, Bojan (Avtor)
ID Plavec, Davor (Avtor)
ID Soklič, Tanja (Avtor)
ID Urbančič, Jure (Avtor)
ID Zidarn, Mihaela, Klinika Golnik, Medicinska fakulteta UL (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://onlinelibrary.wiley.com/doi/10.1111/all.14549
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik
Povzetek:Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage were associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin converting enzyme 2 (ACE2). As a result of SARS-Cov-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT1R) axis associated with oxidative stress. This leads to insulin resistanceas well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block the AT1R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are given: Kimchi in Korea, westernized foods and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects helpful in mitigating COVID-19 severity.
Ključne besede:COVID-19, diet, sulforaphane, Lactobacillus, Angiotensin converting enzyme 2, kimchi, cabbage, fermented vegetable
Status publikacije:V tisku
Verzija publikacije:Recenzirani rokopis
Kraj izida:Velika Britanija
Založnik:John Wiley & Sons
Leto izida:2020
Št. strani:str. [1-38]
Številčenje:Vol. , iss.
PID:20.500.12556/DiRROS-12522 Novo okno
UDK:578:635.34:663.15:
ISSN pri članku:1398-9995
DOI:10.1111/all.14549 Novo okno
COBISS.SI-ID:26203907 Novo okno
Avtorske pravice:2020 EAACI and John Wiley and Sons
Opomba:Nasl. z nasl. zaslona; Opis vira z dne 26. 8. 2020;
Datum objave v DiRROS:07.10.2020
Število ogledov:1341
Število prenosov:315
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Allergy
Založnik:Blackwell
ISSN:1398-9995
COBISS.SI-ID:515009305 Novo okno

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Jezik:Ni določen
Ključne besede:koronavirus, fermentirana zelenjava, kimči, COVID-19


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