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Title:Naše izkušnje z zdravilom bevacizumab v primarnem zdravljenju epitelijskega raka jajčnikov
Authors:Škof, Erik (Author)
Mangaroski, Dushan (Author)
Language:Slovenian
Tipology:1.01 - Original Scientific Article
Organisation:Logo OI - Institute of Oncology
Abstract:Izhodišče: Zdravilo bevacizumab uporabljamo v sklopu primarnega sistemskega zdravljenja napredovalega epitelijskega raka jajčnikov v kombinaciji s paklitakselom in karboplatinom od leta 2013. Namen: Prikazati učinkovitost in varnost zdravljenja z bevacizumabom v redni klinični praksi v sklopu primarnega zdravljenja raka jajčnikov. Metode: V retrospektivno analizo smo vključili bolnice z epitelijskim rakom jajčnikov, ki so se zdravile z bevacizumabom na Onkološkem inštitutu Ljubljana v obdobju od 1. 1. 2013 do 31. 12. 2016. Cilja raziskave sta bila varnost in učinkovitost (preživetje brez ponovitve bolezni, celokupno preživetje) zdravljenja z bevacizumabom. Raziskavo je odobrila etična komisija na Onkološkem inštitutu Ljubljana. Rezultati: V opazovanem obdobju je bilo z bevacizumabom zdravljenih 111 bolnic z napredovalim epitelijskim rakom jajčnikov. Najpogostejši neželeni učinki so bili: bolečine (52 %), krvavitev (45 %), arterijska hipertenzija (44 %). Resne neželene učinke (stopnja 3/4) je imelo 12 % bolnic: venska tromboza/ embolija (3 %), proteinurija (3 %), arterijska hipertenzija (2 %), krvavitev (2 %), bolečine (1 %), fistula (1 %). Mediani čas sledenja je bil 59 mesecev. Mediano preživetje brez ponovitve bolezni je bilo 18 mesecev, mediano celokupno preživetje pa 41 mesecev. Zaključki: Zdravljenje z bevacizumabom v redni klinični praksi je varno in učinkovito ‒ v skladu z do zdaj znanimi rezultati prospektivnih raziskav GOG 218 in ICON 7.
Keywords:rak jajčnikov, epitelijski rak, bevacizumab, kemoterapija
Year of publishing:2020
COBISS_ID:24701955 Link is opened in a new window
UDC:618.1
ISSN on article:1408-1741
OceCobissID:65324032 Link is opened in a new window
DOI:10.25670/oi2020-0030n Link is opened in a new window
Views:364
Downloads:143
Files:.pdf PDF - Presentation file, download (173,87 KB)
 
Journal:Onkologija
Onkološki inštitut
 
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License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:01.06.2020

Secondary language

Language:English
Title:Our experience with bevacizumab in the primary treatment of epithelial ovarian cancer
Abstract:Introduction: Bevacizumab has been used in advanced epithelial ovarian cancer patients as a part of standard primary systemic therapy together with paclitaxel and carboplatin combination chemotherapy since 2013. Aim of study: To evaluate the safety and efficacy of bevacizumab in treatment of patients with advanced epithelial ovarian cancer in daily clinical practice. Methods: Retrospective analysis of patients with advanced epithelial cancer treated with bevacizumab at the Institute of Oncology Ljubljana in the period from 1 Jan 2013 to 31 Dec 2016. The end points of the study were safety and efficacy (relapse-free survival, overall survival). The study was approved by our institutional ethics board. Results: In the observed period, a total of 111 patients with advanced epithelial ovarian cancer were treated with bevacizumab. The most common adverse events were: pain (52%), bleeding (45%), and arterial hypertension (44%). Serious adverse events (grade 3/4) were observed in 12% of patients: 3% venous thrombosis/ embolism, 3% proteinuria, 2% arterial hypertension, 2% bleeding, 1% pain, and 1% fistula. Median follow up was 59 months. Median progression-free survival was 18 months, while median overall survival was 41 months. Conclusions: Treatment with bevacizumab in daily clinical practice is safe and effective – in concordance with published data from prospective studies GOG 218 and ICON 7.

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