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3. Postoperative radiochemotherapy for gastric adenocarcinoma : long term resultsIrena Oblak, Franc Anderluh, Vaneja Velenik, 2009, original scientific article Abstract: Background. To analyze the efficacy of postoperative radiochemotherapy with 5-florouracil (5-FU) and leucovorin (LV) applied in the patients with gastric carcinoma treated in a single institution. Patients and methods. Between 2001 and 2004, 123 patients with resected gastric adenocarcinoma were treated with postoperative concomitant radiochemotherapy with 5-FU and LV. The adjuvant treatment consisted of five cycles of chemotherapy with 5-FU (425mg/m2 IV) andLV (20 mg/m2 IV) and concomitant radiotherapy with the total dose of 45 Gy.Results. The treatment was completed according to the protocol in 82% of patients. The frequency and severity of early toxic effects induced by radiochemotherapy were manageable. Median follow-up time of 56 survivors was 64.5 months (range: 51.7-96.4 months). The 5-year locoregional control (LRC), diseasefree survival (DFS), disease-specific survival (DSS) and overall survival (OS) were 81%, 48.3%, 50.4%, and 48.4%, respectively. The multivariate analysis showed that the tumor involvement of cardia and low intensity of chemotherapy were independent adverse prognostic factors for DSS and OS. More advanced pT-stage and tumors with diffuse growth type according to Lauren were identified as negative independent prognostic factor for OS. They were also on the threshold of statistical significance for DSS. Conclusions. Postoperative radiochemotherapy for gastric carcinoma has acceptable toxicity, and is effective particularly in regard to LRC. High incidence of distant metastases calls for more effective systemic regimens. Published in DiRROS: 08.03.2024; Views: 57; Downloads: 21 Full text (94,49 KB) |
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6. Managing anemia with epoetin alfa in patients with rectal cancerVaneja Velenik, Irena Oblak, Veronika Kodre, 2005, original scientific article Abstract: Background. Anemia is one of the most challenging problems in clinical oncology due to its high prevalence among the patients with malignant diseases. The purposes of our study were: (1) to assess the potential of epoetin alfa therapy to prevent the decline in Hb concentrations that typically accompanies chemotherapy/radiotherapy (ChT/RT) of the patients with rectal cancer; (2) to test the hypothesis that the use of epoetin alfa significantly reduces the transfusion requirements in the patients with rectalcancer treated with ChT/RTafter surgery, and (3) to evaluate the safety profile of the administration of epoetin alfa in the clinical setting. Methods. Sixty patients who underwent surgery for rectal cancer were prospectively enrolled. Group A consisted of 39 patients with Hb concentrations <13 g/dl at the start of ChT/RT following surgery, and group B of 17 patients with Hb concentrations >13 g/dl at the start of ChT/RT following surgery, but whose Hb concentrations fell below 13 g/dl during the ChT/RT protocol. The starting dose of epoetin alfa in both proups was 10,000 IU subcutaneously (se) three times a week (tiw). The following major parameters were evaluated: (1) change in Hb concentrations relative to the baseline as measured at 4-week intervals, (2) allogenic blood transfusion requirements in relation to Hb concentrations, and (3) incidence and severity of adverse events and their potential relationship to epoetin alfa administration. (Abstract truncated at 2000 characters) Published in DiRROS: 14.02.2024; Views: 96; Downloads: 31 Full text (135,72 KB) |
7. Kratek režim obsevanja ali kemoradioterapija ali brez obsevanja v predoperativnem zdravljenju raka dankeVaneja Velenik, 2022, published scientific conference contribution Abstract: Zdravljenje raka danke se je v zadnjem desetletju korenito spremenilo. Predoperativni kratek režim obsevanja ali kemoradioterapija ostajata zlati standard. Z namenom doseganja čim višjega deleža popolnih odgovorov na zdravljenje in s tem izogib operaciji, ki jo lahko spremljajo številni zapleti ter slabša kakovost življenja, se je uveljavil koncept totalnega neoadjuvantnega zdravljenja in strategija sledenja pri bolnikih s popolnim kliničnim odgovorom. Pri podskupini bolnikov z rakom danke, ki izražajo mikrosatelitno nestabilnost, pa imunoterapija odpira novo možnost uspešnega zdravljenja, pri kateri se bolnik lahko izogne vsem standardnim modalitetam, kot so obsevanje, kemoterapija in operacija. Keywords: rak danke, onkološko zdravljenje, rak prebavil Published in DiRROS: 13.01.2023; Views: 348; Downloads: 81 Full text (85,34 KB) |
8. Smernice za obravnavo bolnikov s skvamoznoceličnim karcinomom analnega kanala in kože perinealno (analnega roba)Franc Anderluh, Irena Oblak, Ajra Šečerov Ermenc, Ana Jeromen, Erik Brecelj, Martina Reberšek, Vaneja Velenik, 2022, professional article Keywords: rak analnega kanala, rak analnega roba, radiokemoterapija, obsevanje Published in DiRROS: 15.12.2022; Views: 461; Downloads: 105 Full text (134,47 KB) |
9. Smernice za zdravljenje bolnikov z rakom požiralnika in ezofagogastričnega stika (EGS)Franc Anderluh, Marko Boc, Goran Gačevski, Gorana Gašljević, Samo Horvat, Nežka Hribernik, Marija Ignjatović, Ana Jeromen, Jera Jeruc, Peter Korošec, Tanja Mesti, Srdjan Novaković, Irena Oblak, Janja Ocvirk, Martina Reberšek, Nada Rotovnik-Kozjek, Matevž Srpčič, Ajra Šečerov Ermenc, Borut Štabuc, Vaneja Velenik, Neva Volk, Vesna Zadnik, 2022, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: rak požiralnika, rak ezofagogastritičnega stika, smernice, zdravljenje Published in DiRROS: 07.09.2022; Views: 650; Downloads: 252 Full text (3,50 MB) This document has many files! More... |
10. Neoperativni pristop (watch & wait) po zaključenem totalnem neoadjuvantnem zdravljenju raka danke : prikaz primeraAnja Meden Boltežar, Franc Anderluh, Vaneja Velenik, 2022, professional article Abstract: Sodobno standardizirano zdravljenje lokalno napredovalega raka danke (LNRD) je sestavljeno iz predoperativne kemoradioterapije (KTRT), resekcije s totalno mezorektalno ekscizijo (TME) in pri izbranih bolnikih iz pooperativne kemoterapije (KT). S stopnjevanjem intenzivnosti predoperativnega zdravljenja je prišlo do občutnega porasta patoloških (pCR) in kliničnih popolnih odgovorov (cCR). Pri skrbno izbranih bolnikih s cCR je namesto operativnega zdravljenja možno tudi skrbno spremljanje (angl. Watch & Wait – pristop W&W). Preživetje bolnikov, ki so samo sledeni, ni nič slabše od preživetja operiranih, ob tem pa se izognemo s kirurškim zdravljenjem povezano smrtnostjo in pooperativnim zapletom. V Sloveniji je pristop W&W vključen v zadnja nacionalna priporočila za zdravljenje raka debelega črevesa in danke. Kljub številnim prednostim pristopa W&W še vedno ostaja tveganje za ponovitev in napredovanje bolezni s sistemskim razsojem. Za ugoden izid zdravljenja je ključna skrbna selekcija bolnikov. Težava je predvsem subjektivnost ocene cCR. V prispevku je opisan primer bolnika z LNRD, ki je bil zdravljen s predoperativno KTRT, po čemer je prišlo do cCR. Nato je bil obravnavan s pristopom W&W. Po dveh letih od začetka zdravljenja je prišlo do razsoja bolezni, zaradi česar je bolnik pozneje umrl. Keywords: rak danke, neoperativni pristop, neoadjuvantna terapija Published in DiRROS: 01.07.2022; Views: 686; Downloads: 208 Full text (1,58 MB) |