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Query: "author" (Strojan Primož) .

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1.
Radiotherapy for inverted papilloma : a case report and review of the literature
Primož Strojan, Simona Jereb, Imre Boršoš, Jasna But-Hadžić, Nina Zidar, 2013, original scientific article

Published in DiRROS: 22.03.2024; Views: 40; Downloads: 19
.pdf Full text (961,47 KB)

2.
Effects of electrochemotherapy on immunologically important modifications in tumor cells
Urša Kešar, Boštjan Markelc, Tanja Jesenko, Katja Uršič Valentinuzzi, Maja Čemažar, Primož Strojan, Gregor Serša, 2023, original scientific article

Abstract: Electrochemotherapy (ECT) is a clinically acknowledged method that combines the use of anticancer drugs and electrical pulses. Electrochemotherapy with bleomycin (BLM) can induce immunogenic cell death (ICD) in certain settings. However, whether this is ubiquitous over different cancer types and for other clinically relevant chemotherapeutics used with electrochemotherapy is unknown. Here, we evaluated in vitro in the B16-F10, 4T1 and CT26 murine tumor cell lines, the electrochemotherapy triggered changes in the ICD-associated damage-associated molecular patterns (DAMPs): Calreticulin (CRT), ATP, High Mobility Group Box 1 (HMGB1), and four immunologically important cellular markers: MHCI, MHC II, PD-L1 and CD40. The changes in these markers were investigated in time up to 48 h after ECT. We showed that electrochemotherapy with all three tested chemotherapeutics induced ICD-associated DAMPs, but the induced DAMP signature was cell line and chemotherapeutic concentration specific. Similarly, electrochemotherapy with CDDP, OXA or BLM modified the expression of MHC I, MHC II, PD-L1 and CD40. The potential of electrochemotherapy to change their expression was also cell line and chemotherapeutic concentration specific. Our results thus put the electrochemotherapy with clinically relevant chemotherapeutics CDDP, OXA and BLM on the map of ICD inducing therapies.
Keywords: electrochemotherapy, cisplatin, immune response
Published in DiRROS: 21.03.2024; Views: 49; Downloads: 26
.pdf Full text (7,17 MB)
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3.
Image cytometric nuclear texture features in inoperable head and neck cancer : a pilot study
Margareta Strojan Fležar, Jaka Lavrenčak, Mario Žganec, Primož Strojan, 2011, original scientific article

Abstract: Background. Image cytometry can measure numerous nuclear features which could be considered a surrogate end-point marker of molecular genetic changes in a nucleus. The aim of the study was to analyze image cytometric nuclear featuresin paired samples of primary tumor and neck metastasis in patients with inoperable carcinoma of the head and neck. Materials and methods. Image cytometric analysis of cell suspensions prepared from primary tumor tissue andfine needle aspiration biopsy cell samples of neck metastases from 21 patients treated with concomitant radiochemotherapy was performed. Nuclear features were correlated with clinical characteristics and response to therapy. Results. Manifestation of distant metastases and new primaries was associated (p<0.05) with several chromatin characteristics from primary tumor cells, whereas the origin of index cancer and disease response in the neck wasrelated to those in the cells from metastases. Many nuclear features of primary tumors and metastases correlated with the TNM stage. Conclusions. A specific pattern of correlation between well-established prognostic indicatorsand nuclear features of samples from primary tumors and those from neck metastases was observed. Image cytometric nuclear features represent a promising candidate marker for recognition of biologically different tumor subgroups.
Published in DiRROS: 19.03.2024; Views: 60; Downloads: 20
.pdf Full text (427,02 KB)

4.
5.
Role of radiotherapy in melanoma management
Primož Strojan, 2010, review article

Published in DiRROS: 14.03.2024; Views: 58; Downloads: 20
.pdf Full text (928,27 KB)

6.
Radiotherapy in palliative treatment of painful bone metastases
Andreja Gojkovič Horvat, Viljem Kovač, Primož Strojan, 2009, review article

Published in DiRROS: 08.03.2024; Views: 60; Downloads: 19
.pdf Full text (101,37 KB)

7.
Cysteine cathepsins and stefins in head and neck cancer : an update of clinical studies
Primož Strojan, 2008, review article

Abstract: Background. Cancer of the head and neck represents a diverse group of malignant diseases; so far, no factor in a wide spectrum of biochemical and histological candidate-markers has yet been identified to predict reliably thenatural course of the disease or its response to the therapy to be used in routine clinical practice. Among the factors that promote tumor growth and invasion, several protease systems, implemented in proteolytic degradation of extracellular matrix components, were studied, including papain-like lysosomalcysteine proteases (e.g. cathepsins B and L) and their physiological inhibitors cystatins (e.g. stefins A and B, cystatin C). The aim of the present report is to review the published studies on clinical applicability ofcysteine cathepsins and their endogenous inhibitors stefins in squamous cellcarcinoma of the head and neck and to present recent research results fromthis area conducted jointly by the Institute of Oncology Ljubljana and ENTDepartment of the University Medical Center Ljubljana, Slovenia. Conclusions. According to our experience, immunohistochemical staining of cysteine cathepsins and stefins seems to be of limited value for predicting either treatment response or patientsć survival. However, the results of studies on stefin A in tumor tissue cytosols should be considered hypothesis-generating and deserves further evaluation in the frame of prospective controlled multicentric clinical study.
Published in DiRROS: 08.03.2024; Views: 52; Downloads: 21
.pdf Full text (988,33 KB)

8.
9.
Missing tissue compensation with wax filter compensators in radiotherapy of the head and neck region
Daša Grabec, Primož Strojan, 2005, original scientific article

Abstract: Background. In the conventional radiotherapy of the head and neck region, the inhomogeneity of the absorbed dose in certain clinical situations can exceed ?5% of the nominal dose. Depending on the pattern of dose inhomogeneity, treatment related toxicity is more pronounced and disease control reduced. Theaim of our report is to present the wax filter compensation technique used in our department. Case report. A 46-year-old male with inoperable carcinoma of the oropharynx of clinical stage T3N2c was irradiated with 5 MV linear accelerator photon beams and conventional 3 field technique. In order to obtain more homogenous dose distribution in treated volume, the opposed lateral fields were modified using 2Dwax filter compensators. Results. Using conventional wedge filter compensation, the planed absorbed dose deviations inthe treated volume were in the range of 94% to 113% of the prescribed dose. By modification of the opposed lateral fields with 2D wax filter compensators,the variations of the absorbed dose were reduced to the range from 93% to 105% of the prescribed dose. In the article, the planning and manufacturing as well as dosimetric checking of wax filter compensators are described. Conclusions. With the use of 2D wax filter compensators, the inhomogeneity of absorbed dose distribution was significantly reduced, and thequality of treatment considerably improved.
Published in DiRROS: 14.02.2024; Views: 107; Downloads: 23
.pdf Full text (502,94 KB)

10.
Choroid plexus carcinoma : a case report
Primož Strojan, Mara Popović, Katarina Šurlan Popović, Berta Jereb, 2004, short scientific article

Published in DiRROS: 13.02.2024; Views: 109; Downloads: 23
.pdf Full text (179,15 KB)

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