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Query: "author" (Oblak Irena) .

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Postoperative radiochemotherapy for gastric adenocarcinoma : long term results
Irena Oblak, Franc Anderluh, Vaneja Velenik, 2009, original scientific article

Abstract: Background. To analyze the efficacy of postoperative radiochemotherapy with 5-florouracil (5-FU) and leucovorin (LV) applied in the patients with gastric carcinoma treated in a single institution. Patients and methods. Between 2001 and 2004, 123 patients with resected gastric adenocarcinoma were treated with postoperative concomitant radiochemotherapy with 5-FU and LV. The adjuvant treatment consisted of five cycles of chemotherapy with 5-FU (425mg/m2 IV) andLV (20 mg/m2 IV) and concomitant radiotherapy with the total dose of 45 Gy.Results. The treatment was completed according to the protocol in 82% of patients. The frequency and severity of early toxic effects induced by radiochemotherapy were manageable. Median follow-up time of 56 survivors was 64.5 months (range: 51.7-96.4 months). The 5-year locoregional control (LRC), diseasefree survival (DFS), disease-specific survival (DSS) and overall survival (OS) were 81%, 48.3%, 50.4%, and 48.4%, respectively. The multivariate analysis showed that the tumor involvement of cardia and low intensity of chemotherapy were independent adverse prognostic factors for DSS and OS. More advanced pT-stage and tumors with diffuse growth type according to Lauren were identified as negative independent prognostic factor for OS. They were also on the threshold of statistical significance for DSS. Conclusions. Postoperative radiochemotherapy for gastric carcinoma has acceptable toxicity, and is effective particularly in regard to LRC. High incidence of distant metastases calls for more effective systemic regimens.
Published in DiRROS: 08.03.2024; Views: 57; Downloads: 21
.pdf Full text (94,49 KB)

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Managing anemia with epoetin alfa in patients with rectal cancer
Vaneja Velenik, Irena Oblak, Veronika Kodre, 2005, original scientific article

Abstract: Background. Anemia is one of the most challenging problems in clinical oncology due to its high prevalence among the patients with malignant diseases. The purposes of our study were: (1) to assess the potential of epoetin alfa therapy to prevent the decline in Hb concentrations that typically accompanies chemotherapy/radiotherapy (ChT/RT) of the patients with rectal cancer; (2) to test the hypothesis that the use of epoetin alfa significantly reduces the transfusion requirements in the patients with rectalcancer treated with ChT/RTafter surgery, and (3) to evaluate the safety profile of the administration of epoetin alfa in the clinical setting. Methods. Sixty patients who underwent surgery for rectal cancer were prospectively enrolled. Group A consisted of 39 patients with Hb concentrations <13 g/dl at the start of ChT/RT following surgery, and group B of 17 patients with Hb concentrations >13 g/dl at the start of ChT/RT following surgery, but whose Hb concentrations fell below 13 g/dl during the ChT/RT protocol. The starting dose of epoetin alfa in both proups was 10,000 IU subcutaneously (se) three times a week (tiw). The following major parameters were evaluated: (1) change in Hb concentrations relative to the baseline as measured at 4-week intervals, (2) allogenic blood transfusion requirements in relation to Hb concentrations, and (3) incidence and severity of adverse events and their potential relationship to epoetin alfa administration. (Abstract truncated at 2000 characters)
Published in DiRROS: 14.02.2024; Views: 96; Downloads: 31
.pdf Full text (135,72 KB)

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Primer pregleda literature stereotaktičnega obsevanja trebušne slinavke skozi oči radiološkega inženirja
Irena Oblak, Nena Galunič, Valerija Žager Marciuš, 2023, published scientific conference contribution

Abstract: Rak trebušne slinavke ali kot mu tudi rečemo »tihi rak«, je bolezen, ki jo praviloma odkrijemo pozno, v bolj napredovali obliki, ko je bolezen običajno že neozdravljiva. Kakovost življenja teh bolnikov je lahko zelo okrnjena. Za raziskovanje pomena uvedbe stereotaktičnega obsevanja pri raku trebušne slinavke smo se odločili, ker smo želeli s pomočjo pregleda literature raziskati dobrobit in smiselnost tovrstnega zdravljenja pri omenjenem raku. Uporabili smo deskriptivno metodo in sistematični pregled literature, kjer smo si določili namen, izbrali vire znanstvene literature, opredelili ključne iskalne besede, ter izvedli iskanje. Skupno smo identificirali 16536 virov, s presejanjem smo pridobili 134 virov za natančnejšo analizo. Glede na ustreznost celotnega besedila smo v rezultate vključili 22 najustreznejših virov. Iskanje je potekalo od 10. 1. 2022 do 29. 9. 2022. Za deskriptivni del smo glede na zanesljivost in uporabnost podatkov uporabili skupno 78 virov. Pri mejno operabilnih bolnikih lahko stereotaktična radioterapija pripomore k zmanjšanju tumorja in zajetega žilja in omogoči popolno kirurško odstranitev bolezni. Pri lokalno napredovalih tumorjih, ki so neresektabilni, pa omogoči visoko stopnjo lokalne kontrole, ki je po uspešnosti primerljiva kirurški resekciji. V večini študij v pregledu literature je delež enoletne lokalne kontrole raka trebušne slinavke med 78 % in vse do 94 %, ob zadovoljivo nizki stopnji toksičnosti. Glede na to, da je lokalna kontrola po stereotaktični radioterapiji odlična, je v bodoče pričakovana tudi kombinacija tovrstnega pristopa obsevanja z ostalimi metodami zdravljenja, predvsem sistemskim zdravljenjem z novimi citostatiki, tarčnimi zdravili in morebitno imunoterapijo.
Keywords: rak trebušne slinavke, stereotaktično obsevanje, onkološko zdravljenje
Published in DiRROS: 16.06.2023; Views: 305; Downloads: 118
.pdf Full text (1,38 MB)
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Onkološki bolniki in cepljenje proti covid-19
Urška Ivanuš, Kaja Batista, Tina Firanović, Amela Duratović Konjević, 2021, other monographs and other completed works

Keywords: covid-19, onkologija, cepljenje
Published in DiRROS: 14.07.2022; Views: 615; Downloads: 202
.pdf Full text (371,82 KB)

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Akutna toksičnost pri radioterapiji raka analnega kanala
Valerija Žager Marciuš, Metka Meznarič, Irena Oblak, 2022, published scientific conference contribution (invited lecture)

Keywords: obsevanje, radioterapija, rak analnega kanala
Published in DiRROS: 17.06.2022; Views: 500; Downloads: 141
.pdf Full text (91,42 KB)

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Stereotaktično obsevanje tumorjev jeter
Irena Oblak, Nika Dobnikar, 2020, published professional conference contribution

Keywords: stereotaktično obsevanje, radioterapija, rak jeter
Published in DiRROS: 13.04.2022; Views: 524; Downloads: 206
.pdf Full text (189,37 KB)

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