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Iskalni niz: "avtor" (Kranjc Simona) .

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1.
Gene immunotherapy of colon carcinoma with IL-2 and IL-12 using gene electrotransfer
Tilen Komel, Maša Omerzel, Urška Kamenšek, Katarina Žnidar, Urša Lampreht Tratar, Simona Kranjc Brezar, Klemen Dolinar, Sergej Pirkmajer, Gregor Serša, Maja Čemažar, 2023, izvirni znanstveni članek

Povzetek: Gene immunotherapy has become an important approach in the treatment of cancer. One example is the introduction of genes encoding immunostimulatory cytokines, such as interleukin 2 and interleukin 12, which stimulate immune cells in tumours. The aim of our study was to determine the effects of gene electrotransfer of plasmids encoding interleukin 2 and interleukin 12 individually and in combination in the CT26 murine colon carcinoma cell line in mice. In the in vitro experiment, the pulse protocol that resulted in the highest expression of IL-2 and IL-12 mRNA and proteins was used for the in vivo part. In vivo, tumour growth delay and also complete response were observed in the group treated with the plasmid combination. Compared to the control group, the highest levels of various immunostimulatory cytokines and increased immune infiltration were observed in the combination group. Long-term anti-tumour immunity was observed in the combination group after tumour re-challenge. In conclusion, our combination therapy efficiently eradicated CT26 colon carcinoma in mice and also generated strong anti-tumour immune memory.
Ključne besede: colon carcinoma, gene electrotransfer, gene immunotherapy
Objavljeno v DiRROS: 21.03.2024; Ogledov: 72; Prenosov: 43
.pdf Celotno besedilo (6,92 MB)
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Effect of electroporation on radiosensitization with cisplatin in two cell lines with different chemo- and radiosensitivity
Simona Kranjc Brezar, Maja Čemažar, Alenka Grošel, Živa Pipan Tkalec, Gregor Serša, 2003, izvirni znanstveni članek

Povzetek: Aim. Radiosensitization with cisplatin can be enhanced by electroporation of cells and tumours. The aim of this study was to extend our previous studies ontwo carcinoma tumour models with different chemo-and radiosensitivity in order to evaluate whether this treatment is effective also on less chemo-and radiosensitive tumour cells. Materials and methods. This in vitro study was performed on carcinoma SCK and EAT-E cells. The cytotoxicity of three-modalitytreatment consisting of cisplatin, electroporation and irradiation was determined by the clonogenic assay. Results. The radiosensitizing effect of cisplatin on the two cell lines was greatly enhanced by electroporation. By this combined treatment, less chemo and radiosensitive EAT-E cells were rendered as sensitive as more chemo and radiosensitive SCK cells. Conclusion. The enhancement of cisplatin-induced radiosensitization of cells by electroporation could be beneficially used in the treatment of intrinsically less chemo- and radiosensitive tumours.
Objavljeno v DiRROS: 06.02.2024; Ogledov: 108; Prenosov: 23
.pdf Celotno besedilo (144,48 KB)

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Cryosurgery combined with radiotherapy of tumors in mice
Albert-Peter Fras, Simona Kranjc Brezar, Maja Čemažar, Gregor Serša, 1999, izvirni znanstveni članek

Povzetek: Tlle aim of this study zuas to determine antitumor effectiveness of cryosurgery alone and in comhination with radiotherapy. Cryosurgery of subcutaneous fibrosarcoma SA-1 tumors in A/J mice was moderately effective trcatmcnt. Tumor growth delay was 10.3 * 3.8 days after 5 minute treatment with nitrogen filled cryo-prohe. Shorter treatment times induced less, but dose dependent antitumor effect. In combined treat- ment, tumors were either first treated by cryosurgery for 3 minutes and then locally irradiated with 10Gy for 5 minutes, or irradiated first and thereafter treated by cryosurgery.The antitumor effectiveness of com- bined treatrnent was sequence dependent; the irradiation of tumors before cryosurgery resulted in better antitumor effect than the irradiation after cryosurgery. These results indicate that radiosensitization may not be always expected, in spite of some reports demonstrating that cryosurgery may have radiosensitizing effect in vivo, and that some other mechanisms may be involved contributing to radiationdamage when cryosurgery follows irradiation.
Objavljeno v DiRROS: 22.01.2024; Ogledov: 142; Prenosov: 39
.pdf Celotno besedilo (311,91 KB)

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Razvoj in karakterizacija mišjega modela za študije HPV-pozitivnega raka glave in vratu
Živa Modic, Maja Čemažar, Boštjan Markelc, Andrej Cör, Gregor Serša, Simona Kranjc Brezar, Tanja Jesenko, 2023, objavljeni povzetek znanstvenega prispevka na konferenci

Ključne besede: miši, rak glave in vratu, gensko zdravljenje
Objavljeno v DiRROS: 19.06.2023; Ogledov: 338; Prenosov: 146
.pdf Celotno besedilo (361,47 KB)
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Imunoterapija z bakteriofagi, ki na plaščnih proteinih predstavljajo tumorski peptid MAGE-A1 za zdravljenje malignega melanoma
Nuša Brišar, Katja Šuster, Simona Kranjc Brezar, Andrej Cör, 2023, objavljeni povzetek znanstvenega prispevka na konferenci

Ključne besede: imunoterapija, melanom, bakteriofagi
Objavljeno v DiRROS: 19.06.2023; Ogledov: 316; Prenosov: 137
.pdf Celotno besedilo (361,86 KB)
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Obsevanje in genska terapija s kemokinoma CCL5 ali CCL17 na mišjih modelih karcinoma
Tim Božič, Simona Kranjc Brezar, Boštjan Markelc, Maja Čemažar, 2023, objavljeni povzetek znanstvenega prispevka na konferenci

Ključne besede: miši, obsevanje, gensko zdravljenje
Objavljeno v DiRROS: 19.06.2023; Ogledov: 307; Prenosov: 135
.pdf Celotno besedilo (413,19 KB)
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