1. Neoadjuvant chemotherapy in 13 patients with locally advanced poorly differentiated thyroid carcinoma based on Turin proposal : a single institution experienceNikola Bešić, Marta Dremelj, Andreja A. Schwarzbartl-Pevec, Barbara Gazić, 2015, original scientific article Abstract: There is a paradigm that chemotherapy is ineffective in thyroid carcinoma. The aim of our study was to find out whether neoadjuvant chemotherapy before thyroid surgery had an effect on the size of primary tumour in patients with poorly differentiated thyroid carcinoma (PDTC) based on Turin proposal. Patients and methods. Altogether, 13 patients (8 women, 5 men; median age 61 years) with PDTC based on Turin proposal were treated with neoadjuvant chemotherapy between 1986 and 2005. Tumour diameter was from 4.5 to 18 cm (median 9 cm). Regional and distant metastases were detected in 6 and 9 patients, respectively. Eight patients had pT4 tumour. Results. Altogether, 29 (range 1%5) cycles of chemotherapy were given. Tumour diameter decreased in all the patients and by more than 30% in 5 patients (= 38%). Two of these five patients had also preoperative external beam irradiation (EBRT). Total thyroidectomy, lobectomy and neck dissection were performed in 10, 3 and 5 cases, respectively. R0 and R1 resection was done in 5 and 8 cases, respectively. Eight patients had postoperative EBRT of the neck and upper mediastinum. The 5-year and 10-year cause-specific survival rates of patients were 66% and 20%, respectively. Conclusions. After neoadjuvant chemotherapy a partial tumour regression was observed in 38% of patients with PDTC based on Turin proposal.
Keywords: poorly differentiated thyroid carcinoma, neoadjuvant, chemotherapy, survival
Published in DiRROS: 22.04.2024; Views: 14; Downloads: 2
 Full text (459,46 KB) |
2. |
3. |
4. Izraženost ER in PR pri invazivnem karcinomu dojke : rezultati določanja na 15 029 zaporednih vzorcih z Onkološkega Inštituta v obdobju 2006 do 2021Primož Drev, Olga Blatnik, Jerca Blazina, Juan Antonio Contreras, Gorana Gašljević, Biljana Grčar-Kuzmanov, Andreja Klevišar Ivančič, Snežana Pavlović Djokić, Barbara Gazić, 2022, published professional conference contribution abstract Keywords: onkologija, rak dojke, patologija
Published in DiRROS: 14.02.2023; Views: 411; Downloads: 125
Full text (79,90 KB) |
5. Izraženost hormonskih receptorjev pri invazivnem karcinomu dojke : rezultati določanja na 15029 zaporednih vzorcih z Onkološkega Inštituta v obdobju od 2006 do 2021Barbara Gazić, Olga Blatnik, Jerca Blazina, Juan Antonio Contreras, Gorana Gašljević, Biljana Grčar-Kuzmanov, Andreja Klevišar Ivančič, Snežana Pavlović Djokić, Primož Drev, 2022, published professional conference contribution abstract Keywords: onkologija, rak dojke, patologija
Published in DiRROS: 14.02.2023; Views: 400; Downloads: 89
Full text (87,23 KB) |
6. HER2 pri invazivnem karcinomu dojke – rezultati določanja na 15 184 zaporednih vzorcih z Onkološkega Inštituta v obdobju 2006 do 2021Primož Drev, Olga Blatnik, Jerca Blazina, Juan Antonio Contreras, Gorana Gašljević, Biljana Grčar-Kuzmanov, Andreja Klevišar Ivančič, Snežana Pavlović Djokić, Barbara Gazić, 2022, published professional conference contribution abstract Keywords: onkologija, rak dojke, patologija
Published in DiRROS: 14.02.2023; Views: 365; Downloads: 95
Full text (107,23 KB) |
7. Prediktivna vloga tumorske limfocitne infiltracije za dosego popolnega patološkega odgovora po predoperativnem sistemskem zdravljenju pri zgodnjem raku dojkeKlara Geršak, Barbara Gazić, Andreja Klevišar Ivančič, Primož Drev, Nina Ružić Gorenjec, Cvetka Grašič-Kuhar, 2022, published professional conference contribution abstract Keywords: onkologija, rak dojke, kemoterapija
Published in DiRROS: 03.02.2023; Views: 402; Downloads: 95
Full text (38,68 KB) |
8. |
9. Vpliv opustitve dopolnilne kemoterapije na preživetje bolnic z zgodnjim ER+/HER2+ rakom dojkValentina Jerič Horvat, Damjan Manevski, Barbara Gazić, Primož Drev, Domen Ribnikar, Erika Matos, Boštjan Šeruga, 2022, published professional conference contribution abstract Keywords: onkologija, rak dojke, kemoterapija
Published in DiRROS: 27.01.2023; Views: 369; Downloads: 104
Full text (47,33 KB) |
10. Histološka diagnostika raka dojkBarbara Gazić, 2022, published professional conference contribution Abstract: Diagnozo raka dojk postavi patolog na osnovi mikroskopskega pregleda vzorca tkiva. Patolog na podlagi histološkega pregleda tkiva določa oz. meri tudi klasične prognostične dejavnike in prediktivne dejavnike in jih poda v standardiziranem histološkem izvidu. Na podlagi histološkega izvida načrtujemo zdravljenje bolnic oz. bolnikov z rakom dojk. Patolog določi histološki tip tumorja, stopnjo malignosti tumorja, velikost tumorja, prizadetost pazdušnih bezgavk, prisotnost
invazije v limfne in/ali krvne žile, estrogenske in progesteronske receptorje, status HER2 in proliferacijski indeks MIB1. Za bolnice z majhnim tveganjem za ponovitev bolezni, na zahtevo onkologa, pripravi vzorec tumorskega tkiva za molekularno preiskavo 'Mammaprint' ali 'Oncotype DX ' in ga pošlje v tujino, kjer preiskave opravljajo. Bolnicam oz. bolnikom s trojno negativnim umorjem
in razširjeno boleznijo določi delež PD-L1 pozitivnih tumorskih in/ali imunskih celicah, v primeru klinične indikacije pa pripravi tudi vzorec tumorskega tkiva za določitev prisotnosti mutacij v genu PIK3CA z molekularnimi preiskavami. Poleg prognostičnih in prediktivnih dejavnikov, ki odločilno vplivajo na sistemsko zdravljenje, patolog izmeri oddaljenosti tumorja od kirurških robov in v izvidu poroča o prisotnosti zasevkov v odstranjenih pazdušnih bezgavkah, da lahko načrtujemo dodatno kirurško zdravljenje, če je potrebno. Če je bila bolnica zdravljena z neoadjuvantno kemoterapijo, patolog oceni, ali je v vzorcu dojke ali bezgavk ostanek invazivnega tumorja oz. kakšna je stopnja regresije tumorja po zdravljenju.
Keywords: rak dojk, diagnostika, javno zdravje
Published in DiRROS: 22.12.2022; Views: 431; Downloads: 129
Full text (74,80 KB) |
