1. Effect of post-treated low-temperature plasma nitriding on the wear and corrosion resistance of 316L stainless steel manufactured by laser powder-bed fusionMatjaž Godec, Črtomir Donik, Aleksandra Kocijan, Bojan Podgornik, Danijela Anica Skobir Balantič, 2020, izvirni znanstveni članek Ključne besede: austenitic stainless steel, powder bed fusion, low-temperature plasma nitriding, wear and corrosion behaviour, dislocation cell structure Objavljeno v DiRROS: 25.03.2024; Ogledov: 44; Prenosov: 26 Celotno besedilo (3,28 MB) Gradivo ima več datotek! Več... |
2. Use of plasma nitriding to improve the wear and corrosion resistance of 18Ni-300 maraging steel manufactured by selective laser meltingMatjaž Godec, Bojan Podgornik, Aleksandra Kocijan, Črtomir Donik, Danijela Anica Skobir Balantič, 2021, izvirni znanstveni članek Ključne besede: selective laser melting, 18Ni-300 maraging steel, heat treatment, plasma nitriding, retained and reverted austenite, wear and corrosion behaviour Objavljeno v DiRROS: 25.03.2024; Ogledov: 46; Prenosov: 27 Celotno besedilo (3,37 MB) Gradivo ima več datotek! Več... |
3. Inhibition of cathepsin X enzyme influences the immune response of THP-1 cells and dendritic cells infected with Helicobacter pyloriMiha Skvarč, David Štubljar, Andreja Nataša Kopitar, Samo Jeverica, Bojan Tepeš, Janko Kos, Alojz Ihan, 2013, izvirni znanstveni članek Povzetek: Background. The immune response to Helicobacter pylori importantly determines the outcome of infection as well as the success of eradication therapy. We demonstrate the role of a cysteine protease cathepsin X in the immune response to H. pylori infection. Materials and methods. We analysed how the inhibition of cathepsin X influenced the immune response in experiments when THP-1 cells or dendritic cells isolated from patients were stimulated with 48 strains of H. pylori isolated from gastric biopsy samples of patients which had problems with the eradication of bacteria. Results. The experiments, performed with the help of a flow cytometer, showed that the expression of Toll-like receptors (TLRs), especially TLR-4 molecules, on the membranes of THP-1 cells or dendritic cells was higher when we stimulated cells with H. pylori together with inhibitor of cathepsin X 2F12 compared to THP-1 cells or dendritic cells stimulated with H. pylori only, and also in comparison with negative control samples. We also demonstrated that when we inhibited the action of cathepsin X in THP-1 cells, the concentrations of pro-inflammatory cytokines were lower than when THP-1 cell were stimulated with H. pylori only. Conclusions. We demonstrated that inhibition of cathepsin X influences the internalization of TLR-2 and TLR-4. TLR-2 and TLR-4 redistribution to intra-cytoplasmic compartments is hampered if cathepsin X is blocked. The beginning of a successful immune response against H. pylori in the case of cathepsin X inhibition is delayed. Ključne besede: cathepsin X, macrophage, dendritic cells Objavljeno v DiRROS: 22.03.2024; Ogledov: 42; Prenosov: 24 Celotno besedilo (564,38 KB) Gradivo ima več datotek! Več... |
4. Study of radiation induced changes of phosphorus metabolism in mice by ▫$^{31}P$▫ NMR spectroscopyIgor Serša, Simona Kranjc Brezar, Gregor Serša, Alenka Nemec Svete, Bojan Ložar, Ana Sepe, Jernej Vidmar, Marjeta Šentjurc, 2010, izvirni znanstveni članek Objavljeno v DiRROS: 15.03.2024; Ogledov: 62; Prenosov: 23 Celotno besedilo (699,32 KB) |
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7. Understanding carbide evolution and surface chemistry during deep cryogenic treatment in high-alloyed ferrous alloyPatricia Jovičević Klug, Levi Tegg, Matic Klug Jovičević, Rahul Parmar, Matteo Amati, Luca Gregoratti, László Almásy, Julie M. Cairney, Bojan Podgornik, 2023, izvirni znanstveni članek Ključne besede: cryogenic temperature, surface chemistry, microstructure, atom probe tomography (APT), scanning photoelectron microscopy (SPEM), small angle neutron scattering (SANS) Objavljeno v DiRROS: 08.03.2024; Ogledov: 68; Prenosov: 46 Celotno besedilo (20,08 MB) Gradivo ima več datotek! Več... |
8. Ecotoxicologically relevant cyclic peptides from cyanobacterial bloom (Planktothrix rubecens) - a threat to human and environmental healthBojan Sedmak, Tina Eleršek, Olga Grach-Pogrebinsky, Shmuel Carmeli, Nataša Sever, Tamara Lah Turnšek, 2008, izvirni znanstveni članek Povzetek: Background. The information of the overall production of major cyanobacterial cyclic peptides in a water body is essential for risk assessment and for the prediction of future development of the bloom. A procedure that gives a reviewof both toxic and non-hepatotoxic hydrophilic cyclic peptide production is important to evaluate the ecological conditions in the water environment and to predict the release of dangerous toxic and tumour promoting substances.Methods. The cyclic peptides were identified on the basis of their retention times, characteristic spectra, molecular masses and biological activity. The non-hepatotoxic cyclic peptides were characterised by their inhibition of porcine pancreatic elastase, while cytotoxicity to mammalian cells was tested with the MTT test on B16 cell line. Conclusions. The method presented gives a rapid, simultaneous assessment, preliminary identification and estimation of bioactive cyclic peptides. The synthesis of non-hepatotoxic cyclic peptides can mediate the release various toxic and otherwise biologically active substances that induce systemic genotoxicity in mammals. Ključne besede: tumor promoters, microcystin, anabaenopeptin, planktopeptin, toxic cyanobacterial blooms, environmental health Objavljeno v DiRROS: 07.03.2024; Ogledov: 83; Prenosov: 13 Celotno besedilo (286,29 KB) |
9. Subchronic exposure of rats to sublethal dose of microcystin-YR induces DNA damage in multiple organsMetka Filipič, Bojana Žegura, Bojan Sedmak, Irena Horvat-Žnidaršič, Aleksandra Milutinović Živin, Dušan Šuput, 2007, izvirni znanstveni članek Povzetek: Background. Microcystins (MCs) are cyclic heptapeptides that are considered tobe liver specific toxins. They are potent tumour promoters and recent studies indicate that they are also genotoxic. In this study we measured DNA damage in lymphocytes, liver, kidney (cortex and medulla), lung, spleen and brain cells of male Fisher F344 rats that were exposed to sublethal dose (every second day 10 Ugžkg b.w.č i.p) of microeysrin-YR (MCYR) for one month. Methods. At the end of exposure the animals were sacrificed, the lymphocytes were isolated from blood taken from jugular vein, liver cells were obtained byperfusion with collagenase A and the cells from other organs were isolated by incubating small tissue pieces with eollagenase A. The DNA damage in isolated cells was measured with the single cells gel electrophoresis (SCGE) also called the comet assay. Results. A significant increase of the % tail DNAin MCYR-exposed animals compared to the nonexposed control ones was observed in brain (2.5 fold), liver (2.1 fold), kidney medulla (1.9 fold), kidney cortex (1.8 fold) and lung (1.7 fold) cells, while the DNA from lymphocytes and spleen cells was not affected. Conclusion. This study demonstrated that subehronic exposure to sublethal doses of MCs can induce systemicgenotoxicity in mammals, and it affects not only the liver but also other vital organs. Ključne besede: DNA damage, comet assay, cyanobacteria, bacterial toxins, rats, inbred F344 Objavljeno v DiRROS: 20.02.2024; Ogledov: 106; Prenosov: 28 Celotno besedilo (142,90 KB) |
10. Quasi-copulas as linear combinations of copulasGregor Dolinar, Bojan Kuzma, Nik Stopar, 2024, izvirni znanstveni članek Povzetek: We prove that every quasi-copula can be written as a uniformly converging infinite sum of multiples of copulas. Furthermore, we characterize those quasi-copulas which can be written as a finite sum of multiples of copulas, i.e., that are a linear combination of two copulas. This generalizes a recent result of Fernández-Sánchez, Quesada-Molina, and Úbeda-Flores who considered linear combinations of discrete copulas. Ključne besede: quasi-copulas, copulas, linear combination, affine combination, Minkowski norm Objavljeno v DiRROS: 16.02.2024; Ogledov: 114; Prenosov: 40 Celotno besedilo (604,94 KB) Gradivo ima več datotek! Več... |